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VP18.04: Impact of cardiovascular hemodynamics on surgical and neurodevelopmental outcomes in fetuses with Ebstein's anomaly and tricuspid valve dysplasia
Ultrasound in Obstet & Gyne, 2020
The impact of fetal cardiovascular hemodynamics on surgical and neurodevelopment outcomes in severe forms of Ebstein's anomaly (EA) and tricuspid valve dysplasia (TVD) is unknown. 34 fetuses with EA/TVD were referred from 2014–2019 for fetal ultrasound assessment and clinical management. 19 of this cohort and 30 normal controls underwent fetal CMR to quantify blood flow in the main vessels and calculate cerebral oxygen delivery (cDO2) and consumption (cVO2). Fetal brain volume (BV) was obtained by 3D-SSFP segmentation. Newborns surviving surgery underwent brain MRI and neurodevelopmental follow-up. 26 fetuses were liveborn (76%) and survival was 65% at a mean follow-up of four years in liveborn patients. 10 had brain MRI at birth before discharge: nine had...
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N-Acetyl-d-Galactosamine-Specific Lectin Isolated from the Seeds of Carica papaya
J. Agric. Food Chem., 2011
N-Acetyl-d-galactosamine (GalNAc)-specific lectins are of great interest because they have been reported to detect tumor-associated antigens of malignant cells. We isolated a novel lectin from Carica papaya seeds, named C. papaya lectin (CPL). Purification of the lectin involved ammonium sulfate fractionation and DEAE anion exchange and repeated gel filtration chromatography. Inhibition of CPL causing hemagglutination on human erythrocytes showed that the lectin shows specificity to GalNAc and lactose. Surface plasmon resonance further revealed that the lectin possesses high specificity toward GalNAc with a dissociation constant of 5.5 × 10−9 M. The lectin is composed of 38- and 40-kDa subunits with a molecular mass of ∼804 kDa estimated by size-exclusi...
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Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
Nat Genet, 2018
Seventy percent of breast cancers express the estrogen receptor (ER), and agents that target the ER are the mainstay of treatment. However, virtually all people with ER+ breast cancer develop resistance to ER-directed agents in the metastatic setting. Beyond mutations in the ER itself, which occur in 25-30% of people treated with aromatase inhibitors1-4, knowledge about clinical resistance mechanisms remains incomplete. We identified activating HER2 mutations in metastatic biopsies from eight patients with ER+ metastatic breast cancer who had developed resistance to aromatase inhibitors, tamoxifen or fulvestrant. Examination of treatment-naive primary tumors in five patients showed no evidence of pre-existing mutations in four of five patients, suggesting th...
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Proximal tibia fracture in a patient with incomplete spinal cord injury associated with robotic treadmill training
Spinal Cord, 2015
One case report of proximal tibia fracture in a patient with incomplete spinal cord injury (SCI) associated with robotic treadmill training.To raise the awareness that bone densitometry may be recommended before starting the robotic treadmill therapy, as well as the active vigilance of symptoms after therapy.Institute of Physical and Rehabilitation Medicine, Lucy Montoro Institute for Rehabilitation, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.The patient, female gender, with a fracture of vertebra T12 and arthrodesis from T9 to L1 (American Spinal Injury Association Classification (ASIA-C)). Training on Lokomat consisted of five 30-min weekly sessions, under the supervision of a qualified professional. At the beg...
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Rare Inflammatory Diseases of the White Matter and Mimics of Multiple Sclerosis and Related Disorders
Neuropediatrics, 2013
The spectra of white matter neuroinflammatory diseases and pathological processes inducing inflammatory lesions in the white matter of the central nervous system are wider in children than in adults. The definitions of multiple sclerosis (MS) and of the related clinically isolated syndromes (CIS) and acute disseminated encephalomyelitis (ADEM) have been recently revised leading to a new consensus definition. However, other entities with similarities to these diseases may also develop with monophasic or relapsing white matter inflammation. These conditions include congenital immunogenetic diseases (such as hemophagocytic lymphohistiocytosis), vasculitis, and autoantibody-mediated encephalopathies (Hashimoto encephalopathy, encephalitis with anti-N-meth...
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Restless Giant: The United States from Watergate to Bush v. Gore. By James T. Patterson. (New York: Oxford University Press, 2005. xvi, 448 pp. Paper, $18.95, ISBN 978-0-19-512216-9.)
Journal of American History, 2007
James T. Patterson, the author of the latest volume in the Oxford History of the United States series, won the Bancroft Prize for his volume (Grand Expectations, 1996) in that series on the years immediately preceding the ones covered in Restless Giant. In this sequel, Patterson dutifully points out the social and economic problems Americans faced during the years in question—when liberals, he writes, “continued to bewail the sorrier sides of life in the United States” (p. 183). But his story is basically positive and optimistic, almost cheerful. “This is not primarily a tale of Limits, Decline, or Conflict,” he declares at the outset, because, compared to 1974, “most” Americans in 2001 had lives of “greater affluence, convenience, and comfor...
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Structural and functional 3D mapping of skin tumours with non‐invasive multispectral optoacoustic tomography
Skin Research and Technology, 2016
Recent advances in technology have enabled the development of various non-invasive skin imaging tools to aid real-time diagnosis of both benign and malignant skin tumours, minimizing the need for invasive skin biopsy. Multispectral optoacoustic tomography (MSOT) is a recently developed non-invasive imaging tool, which offers the unique capacity for high resolution three dimensional (3D) optical mapping of tissue by further delivering highly specific optical contrast from a depth of several millimetres to centimetres in living tissues. MSOT enables volumetric, spectroscopic differentiation of tissue, both in vivo and in real time, with and without the application of biomarker-specific probes, and is further able of providing spatial maps of skin chromophores,...
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Taking stock: evaluating the conduct of forensic interviews with children in New Zealand
Psychology, Crime & Law, 2016
This study examined adherence to the New Zealand Specialist Child Witness Interviewing model in 93 interviews with children about sexual abuse allegations. Interviewers (n = 27) demonstrated good adherence to the scripted components of the model during the preparation stage of the interview. When investigating the abuse allegation, interviewers demonstrated a greater use of Direct (‘Wh-’) (57%), and Option-posing prompts (20%) than stipulated by the model and fewer broad open-ended prompts (22%). Very few suggestive questions were posed. In contrast to recommended practice, Direct and Option-posing prompts were not only asked frequently, but were introduced very early in the investigative phase of the interview. Training, supervision and feedback should ...
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Optimization of Active Sites via Crystal Phase, Composition, and Morphology for Efficient Low‐Iridium Oxygen Evolution Catalysts
Angew Chem Int Ed, 2020
Reducing the amount of iridium in oxygen evolution electrocatalysts without compromising their catalytic performances is one of the major requirements in proton-exchange-membrane water electrolyzers. Herein, with the help of theoretical studies, we show that anatase-type TiO2 -IrO2 solid solutions possess more active iridium catalytic sites for the oxygen evolution reaction (OER) than IrO2 , the benchmark OER catalyst. Note that the same is not observed for their rutile-type counterparts. However, owing to their thermodynamic metastability, anatase-type TiO2 -IrO2 solid solutions are generally hard to synthesize. Our theoretical studies demonstrate that such catalytically active anatase-type solid-solution phases can be created in situ on the surfaces of rea...
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A novel mechanism of action for salidroside to alleviate diabetic albuminuria: effects on albumin transcytosis across glomerular endothelial cells
American Journal of Physiology-Endocrinology and Metabolism, 2016
Salidroside (SAL) is a phenylethanoid glycoside isolated from the medicinal plant Rhodiola rosea. R. rosea has been reported to have beneficial effects on diabetic nephropathy (DN) and high-glucose (HG)-induced mesangial cell proliferation. Given the importance of caveolin-1 (Cav-1) in transcytosis of albumin across the endothelial barrier, the present study was designed to elucidate whether SAL could inhibit Cav-1 phosphorylation and reduce the albumin transcytosis across glomerular endothelial cells (GECs) to alleviate diabetic albuminuria as well as to explore its upstream signaling pathway. To assess the therapeutic potential of SAL and the mechanisms involved in DN albuminuria, we orally administered SAL to db/db mice, and the effect of SAL on the album...
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Can familial factors account for the association of body mass index with poor mental health in men or women?
General Hospital Psychiatry, 2013
Abstract Objective This study examined if associations between body mass index (BMI) and mental and physical health were independent of genetic and familial factors. Method Data from 2831 twins (66% female) were used in an epidemiological co-twin control design with measures of BMI and mental and physical health outcomes. Generalized estimating equation regressions assessed relationships between BMI and health outcomes controlling for interdependency among twins and demographics. Within-pair regression analyses examined the association of BMI with health outcomes controlling for genetic and familial influences. Results Adjusted analyses with individual twins found associations in women between BMI and perceived stress ( P =.01) and depression ( P =.002), and...
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A taxonomically broad metagenomic survey of 339 species spanning 57 families suggests cystobasidiomycete yeasts are not ubiquitous across all lichens
American J of Botany, 2019
Premise Lichens are fungi that enter into obligate symbioses with photosynthesizing organisms (algae, cyanobacteria). Traditional narratives of lichens as binary symbiont pairs have given way to their recognition as dynamic metacommunities. Basidiomycete yeasts, particularly of the genus Cyphobasidium, have been inferred to be widespread and important components of lichen metacommunities. Yet, the presence of basidiomycete yeasts across a wide diversity of lichen lineages has not previously been tested. Methods We searched for lichen-associated cystobasidiomycete yeasts in newly generated metagenomic data from 413 samples of 339 lichen species spanning 57 families and 25 orders. The data set was generated as part of a large-scale project to study lichen biod...
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Chain Extension of Carboxy‐Terminated Aliphatic Polyamides and Polyesters by Arylene and Pyridylene Bisoxazolines
Macro Chemistry & Physics, 2004
The bulk reactions between carboxy-terminated polyamide-12 (PA12) or carboxy-terminated poly(butane-1,4-diyl adipate) (PBDA) and 2,2'-(1,3-phenylene)bis(2-oxazoline) (mbox), 2,2'-(2,6-pyridylene)bis(2-oxazoline) (pybox) as chain-coupling agents were studied by size exclusion chromatography, carboxy end-group titration, and NME spectroscopy. The chain-coupling reaction yielded high-molar mass polymers within 20 to 180 min, depending on reaction temperature, starting oligomer molar mass, bisoxazoline/oligomer molar ratio, and the natyre of bisoxazoline. No side-reactions wer observed. Bisoxazoline bypox, used for the first time in the bulk chain extension of carboxy-terminated polymers, exhibited the highest reaction rates. The thermal properties of the result...
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Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
PLoS ONE, 2011
Background Overexpression of the ERBB2 kinase is observed in about one-third of breast cancer patients and the dual ERBB1/ERBB2 kinase inhibitor lapatinib was recently approved for the treatment of advanced ERBB2-positive breast cancer. Mutations in the ERBB2 receptor have recently been reported in breast cancer at diagnosis and also in gastric, colorectal and lung cancer. These mutations may have an impact on the clinical responses achieved with lapatinib in breast cancer and may also have a potential impact on the use of lapatinib in other solid cancers. However, the sensitivity of lapatinib towards clinically observed ERBB2 mutations is not known. Methodology/Principal Findings We cloned a panel of 8 clinically observed ERBB2 mutations, established stable...
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Solidification in heat packs: III. Metallic trigger
AIChE Journal, 2003
The metallic trigger used in commercial heat packs initiates solidification by releasing minute crystals of solid sodium acetate trihydrate into the subcooled solution. These crystals are harbored in submicron cracks on the disk's surface and are released when the disk is flexed. Using scanning electron microscopy, such seed crystals are observed on the surface of a disk after flexing it. Classic nucleation theory is used to investigate the behavior of crystals residing in the cracks on the metallic disk's surface during heating and cooling. Sodium acetate trihydrate crystals are capable of surviving in a 1-nm crack or smaller at regeneration temperatures of the order of 353 K. These seed crystals grow to the mouth of the crack at temperatures below the liqu...
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Feline platelet counting with prostaglandin E1 on the Sysmex XT‐2000iV
Veterinary Clinical Pathol, 2010
The large size of many feline platelets and the high frequency of platelet aggregation often results in falsely low platelet counts in this species. A combination of optical platelet counting to detect even large platelets and the use of prostaglandin E1 (PGE1) to inhibit platelet clumping may increase the accuracy of feline platelet counting.The objective of this study was to compare platelet counts in feline whole blood samples with and without the addition of PGE1 and using different analytical methods in a clinical setting.Platelet counts were determined in 10 feline patients in a referral veterinary hospital using 2 sample types (EDTA, EDTA with PGE1) and 2 methods of analysis (optical counting [PLT-O] and impedance counting [PLT-I]) on the Sysmex XT 20...
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Design and Control of a Complete Azeotropic Distillation System Incorporating Stripping Columns for Isopropyl Alcohol Dehydration
Ind. Eng. Chem. Res., 2012
As demonstrated by Pham and Doherty [Chem. Eng. Sci.1990, 45, 1823] in an ethanol dehydration process and by Arifin and Chien [Ind. Eng. Chem. Res.2007, 46, 2535] in an isopropyl alcohol dehydration process, a three-column heterogeneous distillation sequence which contains a preconcentrator column, an azeotropic column, and an entrainer recovery column is more energy saving than two-column and four-column sequences. The three-column sequence for the isopropyl alcohol (IPA) dehydration process, according to Arifin and Chien, is more energy-saving than the two-column sequence, but the capital cost of the entire sequence is more expensive than that of the two-column sequence. Because the reflux ratio used either in the preconcentration column or the recovery co...
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Quality controls of radiolabeled compounds 131I–Hippuran as PSTNT-BATAN product using electrophoresis method
J. Phys.: Conf. Ser., 2020
The labeled compound 131I-Hippuran has been known for a long time and was still being used by some hospitals as a medical kit for the study of dynamics kidney function. The application of Labelled compound 131I-Hippuran begins by intravenous injection to the patients, then monitor the process of biodistribution, secretion, and excretion of Labelled compound 131I-Hippuran using Renographs. The Bandung TRIGA 2000 reactor has obtained an operating license from BAPETEN in 2017, and has been operating at 800 kW to irradiate various elements including Tellurium to produce radioisotope Iodine-131. Iodine-131 was used as a radioisotope material in Labelled compound 131I-Hippuran, which was produced to fulfill the requests from An-Nur Hospital, Yogyakarta. Labeled co...
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Prediction of performance and emissions of a two-shaft gas turbine from experimental data
Applied Thermal Engineering, 2008
Precise performance evaluation at design and off-design operations is needed for a correct management of power plants. This need is particularly strong in gas turbine power plants, which can quickly react to load variations and are very sensitive to ambient conditions. The paper aims at presenting a simple tool to determine the values of the thermodynamic quantities in each point of the plant and the overall plant performances of a real gas turbine plant. Starting from experimental data, a zero-dimensional model is developed, which properly considers the effect of ambient conditions and water injection for pollutant abatement at different load settings under the action of the control system. In particular, semi-empirical correlations for pollutant emissions ...
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A chemical method for the purification of amino acid-specific transfer RNA's
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
Nucleic acids are the fundamental genetic material of all living organisms. With regard to the complex chemical composition of the macromolecule (nitrogenous bases and the sugar-phosphate chain, giving the polymer a negative charge at neutral pH) and widely varied arrangements of individual types of nucleic acids (native and singlestranded DNA, circular and supercoiled DNA, viral and phage RNAs, rRNA, mRNA, tRNA, DNA–RNA hybrids, natural and synthetic mono- and polythematic polymers, etc.), ionexchange, adsorption and partition chromatographic techniques and gel permeation chromatography can be used to separate nucleic acids. Of greater importance for tRNA are ion-exchange procedures on substituted celluloses and Sephadex, which permit the isolation of pur...
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Epigenetic regulation of the glucose transporter geneSlc2a1by β‐hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice
Genes to Cells, 2016
We carried out liquid chromatography-tandem mass spectrometry analysis of metabolites in mice. Those metabolome data showed that hepatic glucose content is reduced, but that brain glucose content is unaffected, during fasting, consistent with the priority given to brain glucose consumption during fasting. The molecular mechanisms for this preferential glucose supply to the brain are not fully understood. We also showed that the fasting-induced production of the ketone body β-hydroxybutyrate (β-OHB) enhances expression of the glucose transporter gene Slc2a1 (Glut1) via histone modification. Upon β-OHB treatment, Slc2a1 expression was up-regulated, with a concomitant increase in H3K9 acetylation at the critical cis-regulatory region of the Slc2a1 gene in br...
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Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells
Journal of Applied Physiology, 2013
Cell-matrix adhesion is one of the important interactions that regulates stem cell survival, self-renewal, and differentiation. Our previous report (Wu SC, Chang JK, Wang CK, Wang GJ, Ho ML. Biomaterials 31: 631-640, 2010) indicated that a microenvironment enriched with hyaluronan (HA) initiated and enhanced chondrogenesis in human adipose-derived stem cells (hADSCs). We further hypothesize that HA-induced chondrogenesis in hADSCs is mainly due to the interaction of HA and CD44 (HA-CD44), a cell surface receptor of HA. The HA-CD44 interaction was tested by examining the mRNA expression of hyaluronidase-1 (Hyal-1) and chondrogenic marker genes (SOX-9, collagen type II, and aggrecan) in hADSCs cultured on HA-coated wells. Cartilaginous matrix formation, sulfat...
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Exigências nutricionais de proteína, energia e macrominerais de bovinos Nelore de três classes sexuais
R. Bras. Zootec., 2009
Objetivou-se determinar as exigências de energia metabolizável para mantença, as exigências líquidas de proteína, energia e macrominerais para ganho de peso e a eficiência de transformação de exigências líquidas de proteína para ganho em exigências de proteína metabolizável em bovinos Nelore. Foram utilizados 27 animais (nove machos castrados, nove machos não-castrados e nove fêmeas). Três animais de cada classe foram abatidos ao início do experimento como grupo referência. Os 18 animais remanescentes receberam concentrado (1 ou 1,25% do peso vivo) durante 112 dias e foram abatidos ao final, para determinação de sua composição corporal. As exigências líquidas para ganho de peso foram obtidas derivando-se a equação de predição do...
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Determination of alprostadil in rat plasma by ultra performance liquid chromatography–electrospray ionization–tandem mass spectrometry after intravenous administration
Journal of Pharmaceutical and Biomedical Analysis, 2009
A rapid, highly selective ultra performance liquid chromatography-electrospray ionisation-tandem mass spectrometry method (UPLC-ESI-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of alprostadil in rat plasma. After a simple sample preparation procedure involving a one-step liquid-liquid extraction, alprostadil and the internal standard, diphenhydramine, were chromatographed on an ACQUITY UPLC BEH C(18) column with gradient elution using a mobile phase consisting of acetonitrile and water (containing 0.1% formic acid) at a flow rate of 0.25 mL min(-1). The detection was performed on a triple quadrupole tandem mass spectrometer in multiple reaction monitoring (MRM) mode via an electrospray ionization (ESI) source. Th...
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Gastroesophageal Reflux Disease Presenting with Intractable Nausea
Ann Intern Med, 1997
Typical symptoms of gastroesophageal reflux disease are heartburn and regurgitation. A subset of patients present with atypical symptoms, such as chest pain, cough, wheezing, and hoarseness.To review the clinical presentation and treatment of patients who presented with nausea as the primary symptom of gastroesophageal reflux disease.Case series.Outpatient department of a university hospital.10 outpatients who had chronic, intractable nausea and had not responded to empirical therapies.Patients were evaluated by esophagogastroduodenoscopy, 24-hour esophageal pH studies, gastric-emptying tests, electrogastrography, or a Bernstein test.Abnormal acid reflux was found to be the cause of intractable nausea in all 10 patients. In 5 of the 10 patients, esophagitis ...
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High rate of resistance to ceftriaxone and azithromycin among Shigella spp. isolates at three children's referral hospitals in Northeast Iran
Journal of Infection and Chemotherapy, 2020
Acute dysentery is a prevalent case of hospital admission in developing countries, whose most common cause is believed to be Shigella species. Treatment failure employing oral or intravenous antibiotics is an increasing problem among children with dysentery. This is a prospective descriptive study that aims to find the antibiotic resistance pattern of Shigella spp. isolates from children with acute diarrhea in three children's referral hospitals in Mashhad, northeast-Iran. Between February 2018 to September 2019, a total of 233 stool samples were collected from children with inflammatory diarrhea. Shigella spp. were identified by culture and biochemical standard tests. Moreover, polyvalent Shigella antisera were used for serogrouping. The antibiotic suscepti...
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Corrosion Behaviour of Solution Nitrided Stainless Steels
MSF, 1999
The case of near net shape parts made from austenitic steel X2CrNiMo 17-13-2 and austenitic-ferritic steels X2CrNiMoN22-5-3 (wrought) and G-X3CrNiMoCuN26-6-3-3 (cast) is interstitially enriched with nitrogen by the diffusion-based process solution nitriding. In order to obtain good corrosion resistance and mechanical properties, the solution nitriding parameters and the applied cooling time are selected so, that precipitates are avoided (X2CrNiMo 17-13-2, X2CrNiMoN22-5-3) However, in case of a superimposed hydroabrasive load, the presence of nitrides in the case is found to be beneficial. The solution nitrided and the solution annealed conditions of the steels are compared with respect to their susceptibility to corrosion by means of electrochemical polarisa...
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The kinetics of ordering and antiphase domain growth vs. the kinetics of spinodal decomposition and coarsening
Scripta Metallurgica, 1972
Ferritic superalloys with an α/α′ (A2/B2) microstructure constitute an auspicious materials system for high-temperature application and could help satisfy the need for more sustainable creep resistance materials. An exciting way to improve their creep resistance further through alloy development and microstructure engineering is introducing a hierarchical network consisting of α, α′, and α″ (L21). This work investigates the formation and evolution of this microstructure in Fe-Al-Ni-Co(Cr-Mo-Ti-Cu) alloys. It has been identified that the substitution of Fe by Cr leads to the stabilization of γ (fcc, A1) at intermediate temperatures. This amount of γ was found to decrease in the presence of Mo, and the transformation is entirely avoidable by caref...
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Developing sustainable energy efficient buildings – a transnational knowledge transfer experience between Norway and Kosovo
Studies in Higher Education, 2018
The present study investigates the knowledge transfer (KT) processes from Norwegian University of Science and Technology to College ESLG in Kosovo. An inter-organisational knowledge of transfer theoretical framework from the business sector was applied to guide the present study. The data was generated through semi-structured interviews with key university officers, professors, and students in continuous education programmes from College ESLG and documentary evidence analysis from two partner universities. Based on the thematic analysis of the data, the findings demonstrated that the curriculum mapping process, joint lectures between Norwegian and Kosovar professors, joint research, and joint study visits facilitated the KT. While the transfer of knowledge m...
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Energy-Dissipation Performance of Typical Beam-Column Joints in Yingxian Wood Pagoda: Experimental Study
J. Perform. Constr. Facil., 2016
This paper presents an experimental investigation on the structural performance of the beam-column joints of Yingxian Wood Pagoda. A scaled model of typical beam-column joints with dovetail tenon-mortise connection was manufactured and tested. Four failure modes of the joint were identified. These included yield of component under compression perpendicular or parallel to grain, fracture of component under tension perpendicular to grain, and tenon pullout from mortise. The structural performance of the model beam-column joint was revealed from test observations, and the stiffness and the moment-resisting capacity of the prototype beam-column joints of the pagoda were derived based on the similitude theory. An analytical model for estimating the lateral stiffn...
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The Impact of the Self-Directed Search Form R Internet Version on Counselor-Free Career Exploration
Journal of Career Assessment, 2014
College students ( N = 125) volunteered to participate in a study of career exploratory behavior. Participants were randomly assigned to complete the Self-Directed Search Form R (SDS: R) Internet version or to a control group that did not complete the SDS. Results indicated that individuals who completed the SDS: R Internet and reviewed the Interpretive Report engaged in a greater frequency of exploratory career behaviors over 3 weeks and were considering more occupational alternatives than members of the control group. The amount to time spent reviewing the SDS Interpretive Report by members of the treatment group was also associated with greater frequency of career exploratory behavior and with the increased number of occupations being considered. Furtherm...
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Inner-sphere and outer-sphere complexes of yttrium(III), lanthanum(III), neodymium(III), terbium(III) and thulium(III) with halide ions in N,N-dimethylformamide
Faraday Trans., 1991
The formation of chloro, bromo and iodo complexes of yttrium(III), and bromo and iodo complexes of lanthanum(III), neodymium(III), terbium(III) and thulium(III) has been studied by precise titration calorimetry in N,N-dimethylformamide (DMF) at 25 °C. The formation of [YCl]2+, [YCl2]+, [YCl3] and [YCl4]–, and [MBr]2+ and [MBr2]+(M = Y, La, Nd, Tb, Tm) was revealed, and their formation constants, enthalpies and entropies were determined. Stabilities of these bromo complexes are smaller than those of the corresponding chloro complexes, which is expected for hard metal(III) ions. However, formation enthalpies of monobromo complexes of these metal ions, all showing positive values, are significantly smaller than those of the chloro complexes. Furthermore, the...
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Jet ventilation for anterior paediatric scoliosis surgery
Pediatric Anesthesia, 2002
Single-lung anaesthesia for thoracotomy is usually achieved with endobronchial intubation, a double-lumen tube or an endobronchial blocker. High-frequency jet ventilation (HFJV) is seldom described for thoracotomy in children, although it is used for both laryngology procedures in the operating room and as a ventilation mode in intensive care. HFJV was used in three children, aged 10-12 years, who presented for scoliosis correction involving thoracotomy. The jet ventilation catheter was passed through a tracheal tube to reduce the risk of outflow obstruction and allow a smooth conversion to intermittent positive-pressure ventilation when required. Mean airway pressures measured at the tip of the HFJV catheter were at or below 4 cmH2O. Surgical opening of the...
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Selective induction of OX19+ (CD5+) or OX19− (CD5−) alloreactive cytolytic lymphocytes in the rat
Cellular Immunology, 1987
The phenotypes of alloselective cytolytic lymphocytes of the rat are defined by staining of peritoneal cells of alloimmunized donors with monoclonal antibodies, sorting in a cytofluorometer and evaluating cytolytic capacity in a 51Cr-release assay. We demonstrate that alloimmunization of BN rats can result in either OX19+ (CD5+) or OX19− (CD5−) cytolytic alloselective lymphocytes and show that the OX19− (CD5−) cytolytic cells are OX34+ W3/25− (CD4−) OX8+ (CD8+) lymphocytes not exposing surface Ig. It is further demonstrated that the appearance of CD5+ and CD5− cytolytic alloselective lymphocytes are mutually exclusive; immunization with (WF X BN) F1 cells leading exclusively to appearance of OX19+ effector cells while immunization with WF cells...
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Accuracy in clinical arrhythmia detection of a real-time Holter system (Oxford Medilog 4500)
Journal of Electrocardiology, 1990
The accuracy of a real-time analysis Holter system (Oxford Medilog 4500) in detecting ventricular and supraventricular arrhythmias was evaluated. Hand-counted data from randomly selected hours of 152 ECG monitorings of 152 patients were used as the control standard. Accuracy of the system was evaluated on 606 hours for premature ventricular complexes (PVC), PVC couplets and supraventricular extrasystoles (SVE), and on 1,789 hours for ventricular tachycardia (VT), accelerated idioventricular rhythm (AIVR), and supraventricular tachycardia (SVT). Sensitivity and positive predictive accuracy for the Oxford system were (1) 92.9% and 94.9% for PVC; (2) 90.1% and 87.8% for PVC couplets; (3) 98.1% and 56% for AIVR; (4) 80% and 82.3% for VT; (5) 88.6% and 56.5% for ...
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Differential transcriptional control of the two tRNAfMet genes of Escherichia coli K-12
Gene, 1988
The metZ gene of Escherichia coli, which encodes the tRNA(f1Met), was cloned. Using the nucleotide sequence, in vitro transcription, and S1 nuclease mapping analyses, we identified the promoter region, transcriptional start point, the two tandem tRNA(f1Met) structural genes separated by an intergenic space of 33 bp, and the two Rho-independent transcriptional termination sites, in that order. We compared the promoter region of the metZ gene with that of the metY gene, which encodes the tRNA(f2Met) and is located in the promoter-proximal portion of the nusA operon. A G + C-rich sequence (5'-GCGCATCCAC-3'), similar to the corresponding sequence of the rrn promoters that are under stringent control, was found between the Pribnow box and the transcriptional star...
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Serial changes in nuclear magnetic resonance relaxation times after myocardial infarction in the rabbit: Relationship to water content, severity of ischemia, and histopathology over a six‐month period
Magnetic Resonance in Med, 1988
To determine the serial changes in T1 and T2 relaxation times of myocardial infarction, and their relationship to observed changes in water content, regional myocardial blood flow, and histopathology, rabbits were studied at 14 time intervals ranging from 30 min to 6 months after coronary artery ligation. All values were compared to a control group. Hearts were subdivided into infarct and normal segments for measurement of blood flow, water content, and relaxation times (20-MHz spectrometer); other hearts were excised intact for histopathologic studies. T1 relaxation time of infarcted myocardium did not change significantly compared to control over the 6-month study period. T2 relaxation time increased (P less than 0.0001) at 3 days and returned to baseline ...
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Temporal changes in nitrogen and phosphorus codeficiency of plankton in lakes of coastal and interior British Columbia
Can. J. Fish. Aquat. Sci., 2004
Plankton nutrient limitation and deficiency were assessed in six coastal and four interior lakes and reservoirs in British Columbia. Ultimate nutrient limitation was defined as occurring over longer time scales (months to years) and represented the potential attainable biomass or yield. Proximate nutrient deficiency reflected plankton physiological status and, therefore, represented potential limitations of instantaneous growth rates. All lakes and reservoirs were considered to be ultimately P-limited according to total N to total P ratios (TN:TP). However, both P and N deficiencies were found to occur at the same time, suggesting that when deficiency occurs, codeficiency is common. The <3 µm size fraction accounted for a large proportion of P debt, wher...
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Dissolution of lignocellulosic materials and its constituents using ionic liquids—A review
Industrial Crops and Products, 2010
The state of art from the dissolution of cellulose, lignin and wood using ionic liquids is presented in this work. The emphasis is put on the relationship between the properties of ionic liquids and the dissolution capacity. The impact of the following solvation parameters, namely Hildebrand solubility parameter and hydrogen bond basicity are related to the dissolution of lignocellulosic material. Good solvents for cellulose are 1-butyl- and 1-allyl-3-methylimidazolium chlorides as well as 1-ethyl-3-methylimidazolium acetate, whereas for lignocellulosic material the best solvents are 1-ethyl-3-methylimidazolium acetate and 1-allyl-3-methylimidazolium chloride. In allyl group the ethylene functionality facilitates B-interactions with the aromatic lignin struc...
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Quality and use of unlicensed vitamin D preparations in primary care in England: Retrospective review of national prescription data and laboratory analysis
Brit J Clinical Pharma, 2020
Aim To evaluate the type (licensed vs unlicensed) and cost of preparations used to fulfil vitamin D prescriptions in England over time, and to compare measured vitamin D content of selected vitamin D preparations against labelled claim. Methods Retrospective analysis of vitamin D prescription data in primary care in England (2008-2018). Laboratory analysis of 13 selected vitamin D preparations. Results Alongside a rise in the number of oral licensed colecalciferol preparations from 0 to 27 between 2012 and 2018, the proportion of vitamin D prescriptions in which licensed vitamin D preparations were supplied increased from 11.8 to 54.2%. However, the use of unlicensed food supplements (dose strength 400-50 000 IU) remained high, accounting for 39.7% of vitami...
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Die Aufnahme von cAMP und seine Wirkungen auf den Kohlenhydrat- und Lipidstoffwechsel grüner Blätter
Biochemie und Physiologie der Pflanzen, 1978
Summary When cAMP is fed to green plant tissues it is capable of entering cells and is degraded as rapidly in isolated protoplasts as in intact tissues. Effects of cAMP on carbohydrate storage are found when concentrations exceeding 8 · 10− 3 M are used; the rate of CO2-fixation is influenced by > 2 · 10− 4 M cAMP. No effects on lipid fatty acid composition and metabolism could be established, but, after application of > 4 · 10− 4 M cAMP, the incorporation of [14C]-acetate into lipids is raised approximately by 88%. Also, cAMP lowers the formation of leaf-necroses caused by the detergent Tween 20. All effects caused by cAMP could also be obtained by feeding 5′-AMP, therefore these effects are non-specific and there is no indication of...
1781621862
Can titanium mesh influence local recurrence management after implant-based breast reconstruction?
SpringerPlus, 2015
TiLOOP(®) Bra is a permanent titanium-coated polypropylene mesh currently used in post-mastectomy breast reconstruction with implants. This mesh is generally presented as inducing low-grade inflammatory reactions, but only few reports focused on its possible side effects. In the case described here, the use of the mesh led to minor clinical problems that needed to be clinically and surgically managed at the same time as a local relapse.A patient with high-grade ductal carcinoma in situ underwent primary surgery (nipple-sparing mastectomy and one-stage reconstruction using the TiLOOP(®) Bra mesh) and was subsequently referred for radiological and clinical investigation when various nodules became apparent during a follow-up physical examination. Prior to th...
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Variação geográfica em Corydoras paleatus (Jenyns) (Siluriformes, Callichthyidae) do sul do Brasil
Rev. Bras. Zool., 2005
A espécie Corydoras paleatus (Jenyns, 1842) está amplamente distribuída na região Sul do Brasil, ocorrendo desde o Rio Grande do Sul até o norte do Paraná. Estudos populacionais nessa espécie são considerados importantes devido à sua distribuição em uma região com forte interferência ambiental humana e pelo interesse comercial, uma vez que é vendida como peixe ornamental. Dezesseis caracteres morfométricos e seis caracteres merísticos foram utilizados para avaliação morfológica das populações das bacias dos rios Tibagi e Iguaçu (Paraná) e Lagoa dos Quadros (Rio Grande do Sul). Apesar do número de placas laterais ser mais variável nos exemplares do rio Iguaçu, a sobreposição das contagens tanto das placas quanto dos raios das nadad...
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Characterization of the martensitic transformation in the superelastic Ti–24Nb–4Zr–8Sn alloy by in situ synchrotron X-ray diffraction and dynamic mechanical analysis
Acta Materialia, 2015
In this work, the martensitic transformation occurring in the superelastic Ti–24Nb–4Zr–8Sn alloy was investigated by tensile tests, in situ synchrotron X-ray diffraction (SXRD) and dynamic mechanical analysis (DMA). The SXRD results clearly showed the diffraction peaks related to the α″ and β phases and their evolution, under loading and unloading conditions, have highlighted the reversible stress-induced martensitic (SIM) transformation. Consequently, a three step deformation sequence was established from both SXRD analysis and tensile test characterization. On the other hand, the characteristic temperatures related to the martensitic transformation under different applied stresses have been determined from the storage modulus and the damping curv...
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Bi-directional cross-language activation in Chinese Sign Language (CSL)-Chinese bimodal bilinguals
Acta Psychologica, 2022
In bilingual word recognition, cross-language activation has been found in unimodal bilinguals (e.g., Chinese-English bilinguals) and bimodal bilinguals (e.g., American Sign language-English bilinguals). However, it remains unclear how signs' phonological parameters, spoken words' orthographic and phonological representation, and language proficiency affect cross-language activation in bimodal bilinguals. To resolve the issues, we recruited deaf Chinese sign language (CSL)-Chinese bimodal bilinguals as participants. We conducted two experiments with the implicit priming paradigm and the semantic relatedness decision task. Experiment 1 first showed cross-language activation from Chinese to CSL, and the CSL words' phonological parameter affected the cross-lang...
1781621862
Punitive Attitudes Toward Individuals Convicted of Sex Offenses: A Vignette Study
Justice Quarterly, 2019
The public holds stereotypical beliefs about sex crimes, its perpetrators, and its victims, which may influence punitive attitudes toward individuals convicted of sex offenses (ICSOs). Using a nationally representative vignette survey experiment, we examined whether this punitivity toward ICSOs was influenced by deviations from the stereotypical sex crime case. We also explored whether these influences differed between adult and child victim crimes, and whether they differed between sentencing and post-release supervision policy preferences. We found that the respondents consistently recommended more lenient punishments for female perpetrators and harsher punishments for child victim crimes. A child victim rendered other characteristics less relevant. Despit...
1781621862
Hydrocephalus Secondary to Intracranial Hemorrhage in Premature Infants
Pediatr Neurosurg, 1976
Premature (low birth weight) infants are particularly susceptible to intracranial hemorrhage. This frequently arises from the subependymal area and may dissect into the brain or into the ventricles. If the infant survives, hydrocephalus is a frequent sequela. Because of major improvements in the care of premature infants in recent years and the proliferation of intensive care nurseries, increasing numbers of low birth weight infants are surviving and developing hydrocephalus. Seven cases are described of infants who developed hydrocephalus following intracranial bleeding. Initially, ventricular and lumbar punctures were done to attempt to control head growth but this was unsuccessful. Two were treated with temporary external ventriculostomy which did not per...
1781621862
Raindrop Size Distribution Retrieval Using Joint Dual-Frequency and Dual-Polarization Microwave Links
Advances in Meteorology, 2019
Estimation of raindrop size distribution (DSD) is essential in many meteorological and hydrologic fields. This paper proposes a method for retrieving path-averaged DSD parameters using joint dual-frequency and dual-polarization microwave links of the telecommunication system. Detailed analyses of the rain-induced attenuation calculation are performed based on the T-matrix method. A forward model is established for describing the relation between the DSD and the rain-induced attenuation. Then, the method is proposed to retrieve propagation path DSD parameters based on Levenberg–Marquardt optimization algorithm. The numerical simulation for path-averaged DSD retrieval shows that the RMSEs of three gamma DSD parameters are 0.34 mm −1 , 0.81, and 3.21×10 3 ...
1781621862
Mind the gap: The interplay between external and internal actions in the case of corporate social responsibility
Strategic Management Journal, 2016
Research summary: We explore the effect of the interplay between a firm's external and internal actions on market value in the context of corporate social responsibility (CSR). Specifically, drawing from the neo-institutional theory, we distinguish between external and internal CSR actions and argue that they jointly contribute to the accumulation of intangible firm resources and are therefore associated with better market value. Importantly, though, we find that, on average, firms undertake more internal than external CSR actions, and we theorize that a wider gap between external and internal actions is negatively associated with market value. We confirm our hypotheses empirically, using the market-value equation and a sample comprising 1,492 firms in 33 co...
1781621862
The influence of plasma spraying regime and initial substance injection location on the structure of deposited coatings
Surface and Coatings Technology, 2011
Abstract Atmospheric pressure non-equilibrium plasma spray technology has been developed, tested and successfully employed for deposition of catalytic and tribological coatings. Aluminum hydroxide based coatings doped with carbon particles up to 50 μm of thickness were deposited on the stainless steel substrates. Results of experimental investigation on structural characteristics of plasma sprayed coatings in dependence of prevailing external factors are presented. The effect of plasma source operating regime and injection location of precursor dispersed particles (DP) on the morphology and properties of metal oxide coatings was investigated. It has been determined the relation between microstructure of coatings and arc current in plasma source. Significan...
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EFFECTS OF SINTERING TEMPERATURE ON THE PERFORMANCE OF SrSc0.1Co0.9O3-δOXYGEN SEMIPERMEABLE MEMBRANE
Braz. J. Chem. Eng., 2015
Our study investigates the influence of sintering temperature on the microstructure (grain size distribution, grain boundary length), electrical conductivity, and oxygen permeation properties of permeation membranes. For this purpose, SrSc0.1Co0.9O3-δ samples with different microstructures were prepared by varying the sintering temperature from 1100 to 1250 ˚C. The average grain sizes were gradually increased, thus the grain boundary lengths decreased with increased sintering temperatures. The influence of the ceramic microstructure on total electrical conductivity was found to be negligible. The oxygen transport properties of the samples were characterized by permeation measurements as a function of temperature in an air/helium oxygen partial pressure gra...
1781621862
Phloem transport in trees: A generic surface model
Ecological Modelling, 2014
Abstract Phloem transport is the process by which carbohydrates produced in the leaves are translocated throughout a plant. In trees, phloem transport determines the quantity of carbon locally available for radial growth. It is involved in the formation of stem shape and wood patterns. We present a model where the phloem is described as a three-dimensional surface with distributed carbohydrate unloading. Generic, simplified equations of transport for sap and carbohydrates are solved using finite element analysis. With that approach, complex shapes and material distributions can be simulated. We show that predicting sap movement for a branched architecture is easily handled with a surface representation. Numerical experiments predict that, in order to explain...
1781621862
Interaction of hydrogen and oxygen with niobia-supported and niobia-promoted rhodium catalysts
Applied Catalysis, 1991
Abstract Niobia-supported and niobia-promoted rhodium catalysts, which exhibit significant SMSI behavior, have been characterized by temperature-programmed reduction, oxidation and desorption (TPR, TPO and TPD, respectively) of hydrogen. Hydrogen desorption from the rhodium metal decreased with increasing catalyst reduction temperature for the niobia-supported and niobia-promoted rhodium catalysts (SMSI), while no great change was observed for the unpromoted Rh/SiO 2 catalyst (non-SMSI). For the Rh/Nb 2 O 5 catalyst, no spillover of hydrogen occurred even at high temperature (773 K). In contrast, the Rh/SiO 2 catalyst exhibited hydrogen spillover, and the amount was increased substantially by the deposition of niobia promoter. The SMSI states of these cataly...
1781621862
Cosmic ray tracking — a new approach to high-energy γ-astronomy
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1992
Recently the interest of astronomers and high energy physicists has focussed again on cosmic rays, in particular on high energy γ-rays. The CRT (cosmic ray tracking) project proposes a new type of extensive air shower array. A large number of drift chambers of the TPC type will allow the tracking of individual shower electrons. This results in an angular resolution for air showers of σϑ < 0.3°, even near the energy threshold of a few 1012 eV. The design and construction of the detector modules is described. These modules determine tracks in space inside a cylindrical volume of 1.8 m diameter and 0.75 m height with an accuracy of about one millimeter. With a half-scale prototype detector particle distributions in air showers triggered by a scintillator ar...
1781621862
The Second Stage of the Stress-Strain State of Reinforced Concrete Constructions under the Action of Torsion with Bending (Theory)
IOP Conf. Ser.: Mater. Sci. Eng., 2020
Abstract Authors proposed a new approach for determining tangential torsional stresses for arbitrary cross sectional rods, based on simplified assumptions of material resistance. The main feature of this approach is the approximation of rectangular or any complex cross section of reinforced concrete structures by describing a large circle around the cross section and splitting it into small squares with circles inscribed into them. Authors have formulated three theorems. The first one relates the accumulation of tangential stresses (increments) from the edges to the middle of a rectangular cross-section with the formula for determining tangental stresses for round cross-sections. The second theorem allows us to establish a connection between the tangential s...
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Lifting degeneracies in Higgs couplings using single top production in association with a Higgs boson
J. High Energ. Phys., 2013
A bstract Current Higgs data show an ambiguity in the value of the Yukawa couplings to quarks and leptons. Not so much because of still large uncertainties in the measurements but as the result of several almost degenerate minima in the coupling profile likelihood function. To break these degeneracies, it is important to identify and measure processes where the Higgs coupling to fermions interferes with other coupling(s). The most prominent example, the decay of h → γγ , is not sufficient to give a definitive answer. In this paper, we argue that t -channel single top production in association with a Higgs boson, with h → bb , can provide the necessary information to lift the remaining degeneracy in the top Yukawa. Within the Standard Model, the total r...
1781621862
Alignment of defect levels and band edges through hybrid functionals: Effect of screening in the exchange term
Phys. Rev. B, 2010
We investigate how various treatments of exact exchange affect defect charge transition levels and band edges in hybrid functional schemes for a variety of systems. We distinguish the effects of long-range vs short-range exchange and of local vs nonlocal exchange. This is achieved by the consideration of a set of four functionals, which comprise the semilocal Perdew-Burke-Ernzerhof (PBE) functional, the PBE hybrid (PBE0), the Heyd-Scuseria-Ernzerhof (HSE) functional, and a hybrid derived from PBE0 in which the Coulomb kernel in the exact exchange term is screened as in the HSE functional but which, unlike HSE, does not include a local expression compensating for the loss of the long-range exchange. We find that defect levels in PBE0 and in HSE almost coincid...
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84P Wpływ napromieniania na ekspresję receptorów adhezywnych granulocytów obojętnochłonnych krwi obwodowej
Reports of Practical Oncology & Radiotherapy, 1998
Celem pracy była ocena wpływu promieniowania jonizującego na ekspresję receptorów adhezywnych granulocytów obojętnochłonnych krwi obwodowej. Badanie przeprowadzono w dwóch etapach. W pierwszym pobierano krew od chorych z rakiem płuca leczonych napromienianiem. Oznaczenia wykonywano przed oraz w trakcie trwania terapii co 3–4 dni. Po izolacji granulocytów obojętnochłonnych inkubowano komórki za znakowanymi przeciwciałami monoklonalnymi anty ICAM-1 oraz anty ICAM-2. Pomiaru ekspresji badanych receptorów dokonywano przy użyciu cytometrii przepływowej. W drugim etapie badań mierzono ekspresję receptorów ICAM-1 i ICAM-2 na izolowanych, pobranych od osób zdrowych, granulocytach obojętnochłonnych napromienianych w warunkach in vitro. Komó...
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Effect of axial gas dispersion on MTO light–olefin yield: Microreactor data
AIChE Journal, 1996
Pulsed-tracer experiments conducted for horizontal gas flow through a horizontal duct of rectangular cross section (height = 12.7 mm) containing powder in the coherent-expanded vibrated-bed state have been reported (Benge and Squires, 1995; Squires and Benge, 1995). Axial gas dispersion in the duct can be treated by a simple model: the dispersion is a “spreading” superimposed on plug flow, with no gas bypassing and no lagging gas indicative of dead zones. At a given weight hourly space velocity, a large variation in axial Peclet number (Peax) can be achieved by varying length of duct and gas superficial velocity in proportion, with no substantial effect upon gas–solid contacting efficiency. Herein, we report data for the methanol-to-olefin reaction con...
1781621862
Stochastic gradient descent for linear systems with sequential matrix entry accumulation
Signal Processing, 2020
Abstract Conventional stochastic iterative methods are often employed for solving linear systems of equations involving large matrix sizes using low memory footprint. However, their performances are often limited by the unavailability of all the matrix entries, which is often termed as the problem of missing data. Although Ma and Needell [1] have recently proposed a method, termed as mSGD, assuming a model for data missing that results in improved convergence, their result is also affected by constant large variance of the stochastic gradient. In this paper we propose a SGD type method termed as cumulative information SGD (CISGD) for solving a linear system with missing data with an additional provision to accumulate a very small number of matrix entries se...
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Analysis on Surface Roughness and Surface Reflectance through DOE
AMM, 2014
The Lambda 950 spectrometers are designed to investigate and examine surface coating on test specimen by using the light source. The objective of this research is to investigate the factors that affect the surface roughness and reflectance after different parameter of Reactive Ion Etching (RIE) process. There are four parameters to control the RIE process which is temperature, vacuum, RF (Radio Frequency) power and gas flow. The parameters in this research are using a Full Factorial Experimentation technique, the Design of Experiment (DOE). The AFM (Atomic Force Microscope) and Lambda 950 spectrometer are used to analyse the surface roughness and light reflectance of the specimen. The result showed all four parameters of RIE were give effect on surface rough...
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Use of discount cigarettes by smokers in 20 communities in the United States, 1988-1993
Tobacco Control, 1997
To examine characteristics of smokers associated with the use of discount and generic cigarettes.Data for this analysis come from two population-based cross-sectional telephone surveys (1988 survey n = 32952; 1993 survey n = 11783) and a cohort tracking survey (n = 11966) of smokers aged 25-64 years conducted in 20 communities in the United States between 1988 and 1993 as part of the National Cancer Institute's Community Intervention Trial for Smoking Cessation.In each survey, current smokers were asked to report the six-digit UPC code displayed on the side of the pack of their current cigarettes. Respondents who did not have a pack available or who could not locate the UPC code number were asked to report their usual brand of cigarettes smoked. A master lis...
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304. Procedury kontroli jakości napromieniania stosowane w monitorowaniu leczenia dzieci z rozpoznaniem guzów OUN
Reports of Practical Oncology & Radiotherapy, 2003
Cel Radioterapia jest cennym elementem skojarzonego leczenia guzow mozgu u dzieci. Znacząca poprawa wynikow leczenia związana z doskonaleniem technik operacyjnych a takze stosowaniem wielolekowej chemioterapii przyczynila sie do przedluzenia zycia w tej grupie chorych. Aby zmniejszyc ryzyko poźnych uszkodzen popromiennych radioterapia guzow mozgu u dzieci wymaga precyzyjnego planowania leczenia oraz szczegolowej kontroli parametrow napromieniania w trakcie calego leczenia. Kontrola jakości leczenia promieniami obejmuje kontrole ulozenia chorego w trakcie napromienian (wykonywanie zdjec symulacyjnych oraz weryfikacyjnych w trakcie leczenia PVI). Material W latach 1999–2002 w Zakladzie Radioterapii w Gliwicach napromieniano 42 dzieci z rozpoznaniem guzow...
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A system dynamics model for studying manufacturing outsourcing cost dynamics
IJRAPIDM, 2012
Historically companies considered outsourcing manufacturing operations to low-labour-cost regions as a winning formula to effectively compete domestically and globally. However, in the long run, outsourcing strategies may not always be beneficial. Economic growth in developing countries tends to raise labour wages. Increasing global demand for raw materials tends to increase their cost. Added to this, long distance suppliers may prolong lead time, build inventory levels, and reduce responsiveness to demand. To understand how various factors evolve and work together over time to influence the cost-benefit balance in outsourcing, this study presents a system dynamics model of manufacturing outsourcing. This model can map out a supplier’s response to changes ...
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Modeling and Simulation for the Stress Relaxation Behavior of Ti-6Al-4V at Medium Temperature
Rare Metal Materials and Engineering, 2015
Stress relaxation is a significant characteristic of titanium alloys at elevated temperature and load, which is the theoretical foundation of hot sizing and heat treatment. The tensile stress relaxation behaviors of a Ti-6Al-4V sheet over the medium temperature range from 923 K to 1023 K and at several strain levels were investigated. Comprehensive analysis results indicate that the stress relaxation rate increases with the increase of temperature. The residual stress in Ti-6Al-4V alloy reaches the relaxation limit gradually after a period of relaxation. In addition, the stress relaxation limits reach the same value for the different initial stresses at the same temperature. Furthermore, an explicit constitutive equation with a cubic delay function was estab...
1781621861
Image-defined Risk Factors Correlate with Surgical Radicality and Local Recurrence in Patients with Neuroblastoma
Klin Padiatr, 2016
Background: Neuroblastoma is the second most common solid pediatric tumor and the most common cancer to be detected in children younger than 12 months of age. To date, 2 different staging systems describe the extent of the disease: the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Risk Group Staging System (INRGSS). The INRGSS-system is characterized by the presence or absence of so called image-defined risk factors (IDRFs), which are described as surgical risk factors. We hypothesized that IDRFs correlate with surgical complications, surgical radicality, local recurrence and overall survival (OS). Patients and methods: Between 2003 and 2010, 102 patients had neuroblastoma surgery performed in our departm...
1781621861
The precipitation of graphite from the hexaborides of some rare earth elements and yttrium
Carbon, 1966
The reaction between the hexaborides of Nd, Pr, Ce and La and carbon at temperatures greater than 2000°C has been shown to result in a mixture of recrystallized graphite and the appropriate hexaboride. YbB6 and YB6 form graphite, the borocarbides YbB2C2 or YB2C2 and a small amount of the hexaboride. The precipitated graphite, although highly crystalline, had a larger interlayer spacing than hexagonal single crystalline and normal electro-graphite ranging from 3·377 Å to 3·462 Å in samples obtained from different hexaborides. Spectrographic analysis showed the graphite to contain small amounts of rare earth metal and boron. This leads to the suggestion that the increased interlayer spacing is caused by the incorporation of these elements into the graphit...
1781621861
cAMP signaling pathway in depressed patients with psychotic features
Mol Psychiatry, 2002
Abnormalities in protein kinase A (PKA) and Rap1 have recently been reported in depressed patients. The aim of the present study was to investigate the levels of these proteins in platelets from untreated unipolar and bipolar depressed patients with psychotic features. The levels PKA and Rap1 were assessed by Western blot analysis and immunostaining in 37 drug-free patients and 29 healthy subjects. Both unipolar and bipolar patients with psychotic depression have significantly lower levels of platelet regulatory type I and higher levels of catalytic subunits of PKA than controls, whereas the levels of regulatory type II were higher only in psychotic unipolar patients. No significant differences were found in the immunolabeling of both Rap1 and actin among gr...
1781621861
A Study on the Generalization Capability of Acoustic Models for Robust Speech Recognition
IEEE Trans. Audio Speech Lang. Process., 2010
In this paper, we explore the generalization capability of acoustic model for improving speech recognition robustness against noise distortions. While generalization in statistical learning theory originally refers to the model's ability to generalize well on unseen testing data drawn from the same distribution as that of the training data, we show that good generalization capability is also desirable for mismatched cases. One way to obtain such general models is to use margin-based model training method, e.g., soft-margin estimation (SME), to enable some tolerance to acoustic mismatches without a detailed knowledge about the distortion mechanisms through enhancing margins between competing models. Experimental results on the Aurora-2 and Aurora-3 connected ...
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Early application of tail nerve electrical stimulation-induced walking training promotes locomotor recovery in rats with spinal cord injury
Spinal Cord, 2016
This is a randomized controlled prospective trial with two parallel groups. The objective of this study was to determine whether early application of tail nerve electrical stimulation (TANES)-induced walking training can improve the locomotor function. This study was conducted in SCS Research Center in Colorado, USA. A contusion injury to spinal cord T10 was produced using the New York University impactor device with a 25 -mm height setting in female, adult Long–Evans rats. Injured rats were randomly divided into two groups (n=12 per group). One group was subjected to TANES-induced walking training 2 weeks post injury, and the other group, as control, received no TANES-induced walking training. Restorations of behavior and conduction were assessed using th...
1781621861
Growth hormone secretion in premenopausal women before and after ovariectomy: effect of hormone replacement therapy
Fertility and Sterility, 1993
To evaluate the GH response to growth hormone-releasing hormone (GH-RH) stimulation in premenopausal women before and after ovariectomy and after 1 month of estrogen replacement therapy (ERT). Ten women 42 to 49 years of age awaiting combined hysterectomy and ovariectomy for a variety of benign gynecological conditions. Endocrine status was determined by assay of basal levels of gonadotropins (LH, FSH), E2, P, and PRL. Stimulation with GH-RH was performed before and 8 to 10 days after ovariectomy, and after a month of ERT. A significant reduction in GH response to GH-RH was observed after ovariectomy. Estrogen replacement therapy restored GH response to presurgical levels. The results support the role of E2in the stimulated secretion of GH and suggest that E...
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Reconstruction of Great Toe Soft-Tissue Defect with the Retrograde-Flow Medial Pedis Island Flap
Plastic and Reconstructive Surgery, 2014
Background: Several investigators have reported their clinical experience with medial pedis flaps for reconstruction of soft-tissue defects of the distal forefoot. However, they had only a few reports where this flap was used to repair soft-tissue defects of the great toe. Thus, reconstruction of soft-tissue defects of the great toe remains a challenge in reconstructive surgery. The authors describe the use of the medial pedis island flap to cover this region. Methods: This study was divided into two parts: an anatomic study and clinical application. In the anatomic study, 48 cadaveric feet were injected with latex, and then the main vessels distributed at the medial aspect of the foot were observed. Clinically, retrograde-flow medial pedis island flaps were...
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Decision Making for Cryptorchid Castration; a Retrospective Analysis of 280 Cases
Journal of Equine Veterinary Science, 2017
The location of an undescended testicle influences the choice of surgical technique for efficient cryptorchid castration. We review a standardized protocol for preoperative examination to dictate surgical approach to cryptorchidism. Cases are split into two periods: 2004–2006 and 2007–2014. In 2004–2006, conventional cryptorchidectomy and laparoscopic cryptorchid castration (standing) were both offered, but the choice of technique was based primarily on owners' preference for a recumbent or standing procedure. In 2007–2014, ultrasonography was used to locate the testes and dictate the preferred surgical approach; for abdominal testes, laparoscopic intraabdominal spermatic cord ligation without orchidectomy was preferred and for inguinal testes, conve...
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Murine mammary stem/progenitor cell isolation: Different method matters?
SpringerPlus, 2016
Murine mammary stem/progenitor cell isolation has been routinely used in many laboratories, yet direct comparison among different methods is lacking. In this study, we compared two frequently used digestion methods and three sets of frequently used surface markers for their efficiency in enriching mammary stem and progenitor cells in two commonly used mouse strains, C57BL/6J and FVB. Our findings revealed that the slow overnight digestion method using gentle collagenase/hyaluronidase could be easily adopted and yielded reliable and consistent results in different batches of animals. In contrast, the different fast digestion protocols, as described in published studies, yielded high percent of non-epithelial cells with very few basal epithelial cells liberate...
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Breast cancer in aging women. A population-based study of contrasts in stage, surgery, and survival
Cancer, 1989
Over 43% of the newly diagnosed breast cancers in the US occur in women 65 years or older. Yet little attention is devoted to the age-associated aspects of this malignancy. This study uses data on more than 125,000 women diagnosed from 1973 to 1984 to examine the influence of advancing age on breast cancer. The National Cancer Institute's Surveillance, Epidemiology, and End Results Program provides information on disease stage, surgery, histologic type, and survival time to compare and contrast women in all age groups. Women who present initially with distant disease are more likely to be elderly. Certain surgical procedures are used less frequently for older women. No unusual age variations in histologic features are noted. Elderly women do as well as young...
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Of Techno-Ethics and Techno-Affects
Feminist Review, 2019
As digital labour becomes more widespread across the uneven geographies of race, gender, class and ability, and as histories of colonialism and inequality get drawn into these forms of labour, our imagination of what these worlds contain similarly needs to expand. Beyond the sensationalist images of the ‘brogrammer’ and the call-centre worker lie intersecting labour practices that bring together histories of bodies and materiality in new ways. In the recent past, these entanglements have yielded oppressive results. As scandals over predictive policing, data mining and algorithmic racism unfold, digital labourers need both to be accounted for in analyses of algorithmic technologies and to be counted among the designers of these platforms. This article att...
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Right Hemidiaphragmatic Elevation With a Right-to-Left Interatrial Shunt Through a Patent Foramen Ovale
Chest, 2001
A right-to-left shunt (RLS) is an uncommon complication of a patent foramen ovale (PFO) that may cause hypoxemia from venous admixture and ischemic complications from paradoxic embolization. This report presents the third described patient whose RLS through a PFO and profound hypoxemia developed in association with right hemidiaphragm dysfunction (but without a pressure gradient driving the right-to-left flow). In addition to extending the available experience with this unusual clinical event, we report on the successful closure of the PFO by a catheter-deployed double-umbrella device, after the positioning of which the patient’s oxygenation normalized. A right-to-left shunt (RLS) is an uncommon complication of a patent foramen ovale (PFO) that may cause h...
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UV-light induced photocatalytic decolorization of Rhodamine 6G molecules over BiOCl from aqueous solution
Chemical Engineering Journal, 2010
The sorption and photocatalytic decolorization (under irradiation of monochromaticitic 355 nm-pulsed-laser) behaviors of Rhodamine 6G (Rh 6G) in presence of BiOCl semiconductor in aqueous solution were studied in this paper. The sorption kinetic and isotherm behaviors of Rh 6G over BiOCl catalyst were investigated and discussed through pseudo-second-order/intraparticle diffusion models and Langmuir/Freundlich models, respectively. The effect of critical parameters such as catalyst dosage, initial concentration of Rh 6G, and laser pulse energy on the photocatalytic decolorization process was investigated. The photocatalytic decolorization and photonic efficiency of BiOCl was compared with standard catalyst (TiO2) and the obtained results were discussed in ter...
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Natural products for male androgenetic alopecia
Dermatologic Therapy, 2022
Androgenetic alopecia (AGA) is the most common cause of hair loss in men, often requiring medical attention. The US FDA approved topical minoxidil and oral finasteride to treat AGA. Topical minoxidil requires a long-term application to observe improvement; oral finasteride may cause undesirable side effects. Therefore, natural products may be an alternative when patients are skeptical about these two conventional treatments. Physicians may also suggest natural products in conjunction with topical minoxidil or oral finasteride to enhance clinical outcomes. This article reviews the prospect of natural products in treating male AGA. A systematic search was conducted in PubMed, CINAHL, Scopus, Web of Science, and EMBASE (Ovid) on July 19, 2021. In addition, the ...
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Handbuch der Gewebelehre der Menschen Lehrbuch der Histologie der Menschen, einschliesslich der mikroskopischen Technik Lehrbuch der vergleichenden mikroskopischen Anatomie der Wirbelthiere
Nature, 1896
TO place the classical treatise of the famous Würzburg professor in a list of new books on histology, must at once strike all readers who have any acquaintance with, that science as manifestly absurd. Is not this the book from whose stores of knowledge our predecessors in the teaching of the subject drew so largely, and which has served ever since as the foundation upon which modern histology has been built? Is not this the book, the-translation of which by Busk and Huxley, under the auspices of the Sydenham Society, rendered the names both of its author and of its translators familiar to a long, past generation of students? Handbuch der Gewebelehre der Menschen. Von A. Koelliker. 6te Auflage, Erster Band, pp. 409, 1889; Zweiter Band, Erste Hälfte, pp. 372...