Sci-Hub

1781608757

Molecular Detection of Borrelia burgdorferi Sensu Lato and Anaplasma phagocytophilum in Ticks Collected from Dogs in Urban Areas of North-Eastern Poland

Pathogens, 2020

From 2016 to 2018, ticks were collected from 272 dogs admitted to veterinary clinics in the city of Olsztyn (north-eastern Poland). Among 522 collected ticks, 423 were identified as Ixodes ricinus (413 females and 10 males) and 99 as Dermacentor reticulatus (62 females and 37 males). Non-engorged (86 individuals) and engorged (436 individuals) ticks were screened for the presence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum DNA. Borrelia and A. phagocytophilum species detection was determined based on the sequence of the fla B and 16S RNA genes, respectively. DNA of B. burgdorferi s.l. was identified in 31.6% (165/522, 95% CI: 27.6–35.8%) of ticks (I. ricinus 151/423, 35.7%, 95% CI: 31.1–40.4%; D. reticulates 14/99, 14.1%, 95% CI: 7.9...

1781608757

Age-dependent survival rate of the colonial Little Tern (Sternula albifrons)

PLoS ONE, 2019

Many ground-nesting bird species are suffering from habitat loss and population decline. Data on population ecology and demography in colonies of threatened species are thus essential for designing effective conservation protocols. Here, we used extensive ringing and observation data to estimate directly, for the first time, the survival rate of juvenile and adult Little Tern (Sternula albifrons), as well as testing for a possible effect of age on probability of survival. We estimated adult annual survival rate to be 0.77, and juvenile (first year) survival to be 0.49 with a possible linear decrease in the survival rate of the juveniles that ranged from 0.681 to 0.327. We found no evidence that survival was age-dependent among the early age classes after the...

1781608757

Fabrication of Cu2O/Fe–O heterojunction solar cells by electrodeposition

Thin Solid Films, 2015

Cu2O/Fe–O heterojunction solar cells were successfully fabricated by electrodeposition method. The as-deposited thin film exhibited signature Raman peaks associated to γ-FeOOH. By thermal annealing in air at 100–400 °C, different Fe2O3 polymorphs were produced. Both as-deposited and annealed Fe–O films showed n-type conductivity with approximated band gap of 2.1–2.3 eV. Resistivity was ~ 680 Ω cm for γ-FeOOH and > 700 Ω cm for Fe2O3 films. Cu2O as the p-type layer was partnered with as-deposited and annealed Fe–O thin films to fabricate different heterojunctions based on Fe oxides compounds. Remarkably, all the fabricated Cu2O/Fe–O heterostructures exhibited photovoltaic characteristics (open circuit voltage, VOC = 38–108 mV and short circ...

1781608757

The depth structure of motivic multiple zeta values

Math. Ann., 2018

In this paper, we construct some maps related to the motivic Galois action on depth-graded motivic multiple zeta values. From these maps we give some short exact sequences about depth-graded motivic multiple zeta values in depth two and three. In higher depth we conjecture that there are exact sequences of the same type. We will show from three conjectures about depth-graded motivic Lie algebra we can nearly deduce the exact sequences conjectures in higher depth. At last we give a new proof of the result that the modulo $$\zeta ^{\mathfrak {m}}(2)$$ version motivic double zeta values are generated by the totally odd part. We reduce the well-known conjecture that the modulo $$\zeta ^{\mathfrak {m}}(2)$$ version motivic triple zeta values are generated by the ...

1781608757

Estimates of genetic parameters associated with lactation feed intake and growth and composition traits measured during a performance test

J Animal Breeding Genetics, 2014

Days to reach 113.4 kg, adjusted backfat depth and adjusted loin muscle area to 113.4 kg were evaluated on pure-bred Landrace (n = 15 660) and Yorkshire (n = 14 808) boars and gilts. Daily lactation feed intake (LFI) was recorded within parity records from pure-bred Yorkshire (n = 1587) and Landrace (n = 2197) females during day 1-22 of lactation, and LFI curves were predicted using a mixed model. Evaluation of feed intake differences between 2 consecutive days of lactation resulted in the following periods: day 1-6 (PB1), day 7-10 (PB2) and day 11-18 (PB3). Average rate of change in intake (ARC), average daily intake (ADI) and variation from predicted daily LFI values (VAR) metrics were computed for each period of lactation. Gibbs sampling was used to estim...

1781608757

Paris Saponin I Sensitizes Gastric Cancer Cell Lines to Cisplatin via Cell Cycle Arrest and Apoptosis

Med Sci Monit, 2016

BACKGROUND:Dose-related toxicity is the major restriction of cisplatin and cisplatin-combination chemotherapy, and is a challenge for advanced gastric cancer treatment. We explored the possibility of using Paris saponin I as an agent to sensitize gastric cancer cells to cisplatin, and examined the underlying mechanism. MATERIAL AND METHODS:Growth inhibition was detected by MTT assay. The cell cycle and apoptosis were detected using flow cytometry and Annexin V/PI staining. The P21waf1/cip1, Bcl-2, Bax, and caspase-3 protein expression were detected using Western blot analysis. RESULTS:The results revealed that PSI sensitized gastric cancer cells to cisplatin, with low toxicity. The IC50 value of cisplatin in SGC-7901 cell lines was decreased when combined wi...

1781608757

Do Bacterial “Virulence Factors” Always Increase Virulence? A Meta-Analysis of Pyoverdine Production in Pseudomonas aeruginosa As a Test Case

Front. Microbiol., 2016

Bacterial traits that contribute to disease are termed ‘virulence factors’ and there is much interest in therapeutic approaches that disrupt such traits. What remains less clear is whether a virulence factor identified as such in a particular context is also important in infections involving different host and pathogen types. Here, we address this question using a meta-analytic approach. We statistically analyzed the infection outcomes of 76 experiments associated with one well-studied virulence factor – pyoverdine, an iron-scavenging compound secreted by the opportunistic pathogen Pseudomonas aeruginosa. We found that this factor is consistently involved with virulence across different infection contexts. However, the magnitude of the effect of pyover...

1781608757

The potential probiotic Lactobacillus rhamnosus CTC1679 survives the passage through the gastrointestinal tract and its use as starter culture results in safe nutritionally enhanced fermented sausages

International Journal of Food Microbiology, 2014

The human-derived potential probiotic strain Lactobacillus rhamnosus CTC1679 was used as a starter culture in reduced fat and sodium low-acid fermented sausages (fuets) to assess its ability to survive through the gastrointestinal tract (GIT) in a human intervention study consisting of 5 healthy volunteers who consumed 25 g fuet a day for 21 days. Faecal samples were analysed during and after consumption. L. rhamnosus CTC1679 produced a transient colonisation of the human GIT and persisted during the ingestion period of fuet containing L. rhamnosus CTC1679 at levels ca. 8log CFU/g. After 3 days of non-consumption, the strain was still recovered in the faeces of all the volunteers. To evaluate the safety of the nutritionally enhanced manufactured fuets, a cha...

1781608757

Defining microbial invasion of the bloodstream: a structured review

Infectious Diseases, 2020

Background: Microbial invasion of the bloodstream is associated with a major burden of illness. Despite its importance, there is inconsistency in utilization of terms used to define it. Objective: To characterize the contemporary use of terms to define microbial invasion of the bloodstream for surveillance and research purposes. Methods: Structured review of publications reported from 2000 to 2019. Results: The search strategy retrieved 10,095 citations of which bloodstream infection, bacteraemia and fungaemia were included in 2813, 6900 and 1054 articles, respectively. There was a tripling of the number of annual citations during the study and although bacteraemia was most frequent, there was a progressive increase in the use of the term bloodstream infecti...

1781608757

Perspectives of pregnant women during the COVID-19 pandemic: A qualitative study

Women and Birth, 2022

The current COVID-19 pandemic has been shown to have profound effects on pregnant women globally, particularly, on their psycho-social wellbeing. Despite this, there has been limited qualitative inquiry into the experiences of pregnant women during the pandemic.This original research aimed to study the perspectives of pregnant women in Australia in relation to the impact of the COVID-19 pandemic on their pregnancy experience.A qualitative descriptive study design with semi-structured interviews was adopted. The study was performed in Melbourne, Australia. A total of fifteen interviews were conducted. Data was analysed thematically to develop major themes and subthemes.A total of four major themes were developed: support for a positive experience, impact on p...

1781608757

Synthesis, pH-induced “on–off–on” luminescence switching, and partially intercalative DNA-binding and DNA photocleavage properties of an β-d-allopyranoside-grafted ruthenium(II) complex

Journal of Inorganic Biochemistry, 2012

A new ruthenium(II) complex [Ru(Happip)(3)](ClO(4))(2) {Happip=2-(4-(β-D-allopyranoside)phenyl)imidazo[4,5-f][1,10]phenanthroline} was synthesized and characterized by elemental analysis, (1)H NMR and matrix-assisted laser desorption ionization mass spectrometry. Calf-thymus DNA-binding properties were studied by DNA viscosity measurements and spectroscopic methods of UV-visible (UV-vis) absorption and luminescence titrations, steady-state emission quenching, DNA competitive binding with ethidium bromide and DNA melting experiments, indicating that the complex partially intercalates into the DNA with a large binding constant greater than 10(6)M(-1). The pH effects on UV-vis absorption and emission spectra of the complex were studied, demonstrating that the ...

1781608757

Review: moderate weight loss reduces functional disability but does not reduce pain in obese patients with knee osteoarthritisCommentary

Evid Based Nurs, 2008

R Christensen Correspondence to: Mr R Christensen, Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Frederiksberg, Denmark; Robin.Christensen@frh.regionh.dk In obese patients with knee osteoarthritis (OA), does weight loss reduce pain and improve functional disability? ### Data sources: MEDLINE (1966 to April 2006), EMBASE/Excerpta Medica (1980 to April 2006), CINAHL (1982 to April 2006), Web of Science (1945 to April 2006), Scopus (1966 to May 2006), Cochrane Musculoskeletal Group’s trials register, Cochrane Central Register of Controlled Trials, conference abstracts, and reference lists. ### Study selection and assessment: randomised controlled trials (RCTs) that evaluated any intervention reporting weight change as the only dif...

1781608757

QoS‐aware mobility support architecture for next generation mobile networks

Wireless Communications, 2005

Provision of quality of service (QoS) support with mobility has received impetus from the evolution that has occurred in mobile communication technologies. This is especially the main driver behind 4G/B3G networks that will enable a user to access any type of services anytime, anywhere, and anyhow. In this paper, we first review some of the state-of-the-art techniques in the area of QoS and resource management based mobility. We then propose an augmented 4G/B3G architecture that addresses key limitations in the salient 4G architectures examined in the literature. Our proposed novel augmentations in mobility, QoS, and resource management schemes consolidate operation of the 4G architecture. The other defining attributes of our proposed 4G architecture are tha...

1781608757

Undiagnosed chronic obstructive pulmonary disease in patients admitted to an acute assessment unit

European Clinical Respiratory Journal, 2017

ABSTRACT Introduction: Chronic obstructive pulmonary disease (COPD) is very prevalent worldwide, yet underdiagnosed Aim: This study investigates feasibility of performing spirometry in patients in need of acute hospital admission as well as the prevalence of undiagnosed COPD in the same cohort. Methods: During a two-week period, all patients admitted to three large acute assessment units were evaluated. Patients ≥ 18 years, able to perform spirometry, with no surgery to the thorax or abdomen within the last weeks and no known COPD was included. Patients with FEV1/FEV6 ≤ 0.7 or FEV1 < 80% or FEV6 < 80% were offered follow-up visit after 6 weeks. Results: Of the 1145 admitted patients, 46% were eligible: 28% of those had an abnormal spirometry. The offered...

1781608757

Effects of Hyper- and Hypothyroidism on Serum LH and FSH Levels in Intact and Gonadectomized Male and Female Rats

Endocrinology, 1975

The effects of hypo- and hyper-thyroidism on serum LH and FSH were determined in both intact and castrated male and female rats. Thyro-parathyroidectomy (Tx) for 30 days in rats with intact gonads resulted in a significant reduction in serum LH and FSH, and also in a decrease in serum testosterone in males. Administration of 2.5 mug thyroxine (T4)/100 g BW to Tx rats of both sexes returned serum LH and FSH levels to those of intact rats, and in males also restored normal serum testosterone levels. Tx superimposed upon castration resulted in a significantly greater increase in serum LH and FSH than produced by castration alone. Administration of 2.5 mug T4/100 g body weight to castrate-Tx rats reduced serum LH and FSH values to those of castrate rats, whereas...

1781608757

Decentralized Coordinated Tracking with Mixed Discrete–Continuous Decisions

Journal of Field Robotics, 2013

In this paper, we study the problem of dynamically positioning a team of mobile robots for target tracking. We treat the coordination of mobile robots for target tracking as a joint team optimization to minimize uncertainty in target state estimates over a fixed horizon. The optimization is inherently a function of both the positioning of robots in continuous space and the assignment of robots to targets in discrete space. Thus, the robot team must make decisions over discrete and continuous variables. In contrast to methods that decouple target assignments and robot positioning, our approach avoids the strong assumption that a robot's utility for observing a target is independent of other robots’ observations. We formulate the optimization as a mixed inte...

1781608757

Hepatitis After Sevoflurane Exposure in an Infant Suffering from Primary Hyperoxaluria Type 1

Anesthesia & Analgesia, 2004

In Brief An 11-mo-old child with primary hyperoxaluria was scheduled for a nephroureteromia procedure. Anesthesia was induced and maintained with sevoflurane. Two days after the operation, a hepatomegaly was diagnosed, and a considerable increase in liver enzymes was observed. These pathologic findings disappeared without treatment within 7 days. In a subsequent operation 2 wk later, general anesthesia was performed (sevoflurane was avoided). After the second operation, no pathologic findings could be detected. Nothing in this patient’s disease or the conduct of the anesthesia suggested a cause for the injury other than an idiosyncratic response to sevoflurane. IMPLICATIONS: Sevoflurane is a frequently used inhaled anesthetic in pediatric anesthesia and is...

1781608756

The role of the sympathetic nervous system in the cardiovascular responses to angiotensin in the pithed rat

British J Pharmacology, 1969

1. Angiotensin (200-500 ng, intravenously) produced a biphasic pressor response accompanied by reflex bradycardia in rats anaesthetized with sodium pentobarbitone. In pithed rats and in anaesthetized animals treated with a ganglion blocking agent there was a similar pressor response but an increase in the heart rate which was coincident with the second phase of the pressor response. In pithed preparations an increase in cardiac contractile force accompanied the heart rate changes.2. Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat. Propranolol abolished the chronotropic and inotropic action of angiotensin, but left the biphasic pressor response unaltered. Bethanidine, or pretreatment ...

1781608756

Conformational Control of Nitric Oxide Synthase Activity: Results from Time-Resolved and Single-Molecule Fluorescence

Biophysical Journal, 2017

Nitric oxide synthase (NOS) generates a signaling molecule, nitric oxide, which is essential for processes such as vasodilation and neurotransmission. The enzyme forms homodimers containing cofactors FAD, FMN, and heme, each housed in subunits of the enzyme. Synthase activity in NOS is activated by calmodulin (CaM), which binds to a region adjacent to the FMN domain. Conformational motion is necessary to position sequential electron donor-acceptor pairs adjacent to one another for transfer of electrons from the FAD domain to the FMN domain and then to the oxygenase domain of the opposite member of the homodimer. We characterized the conformations and dynamics of endothelial and neuronal NOS with bound CaM by time-resolved and single-molecule detection of flu...

1781608756

Increased β-adrenergic receptor density in an experimental model of cardiac transplantation

The Journal of Thoracic and Cardiovascular Surgery, 1983

We examined β-adrenergic receptor density, basal, maximal isoproterenol and fluoride-stimulated adenylate cyclase activities, and morphologic characteristics of rabbit and rat native and heterotopic isograft cardiac tissue. Four weeks after graft placement there were only subtle histologic differences between native and graft tissue. Membrane preparations from isografts of rabbits demonstrated increases in β-receptor density (maximum [3H]DHA binding = 111 ± 19.3 fmol/mg versus 52.4 ± 4.9 in native hearts, p < 0.05). In a small number of experiments, rat isografts also demonstrated a suggestive increase in β-receptor density (69.8 ± 7.1 fmol/mg versus 40.2 ± 7.3 in native hearts). Isoproterenol-stimulated adenylate cyclase activity was greater in rabbi...

1781608756

Iterative development of MobileMums: a physical activity intervention for women with young children

Int J Behav Nutr Phys Act, 2012

To describe the iterative development process and final version of 'MobileMums': a physical activity intervention for women with young children (

1781608756

PARRONDO'S GAME MODEL TO FIND NUMERICALLY STABLE ATTRACTORS OF A TUMOR GROWTH MODEL

Int. J. Bifurcation Chaos, 2012

In this paper, we present a simple and accessible way to enhance the stable behaviors of a chaotic dynamical system which models a cancer growth, as presented in [Itik & Banks, 2010]. The algorithm presented in [Danca et al., 2012], approximates numerically any attractor of a system belonging to a defined class of dynamical systems, by alternating the control parameter in relatively short periods of time. When switching the control parameter within a set of values corresponding to some chaotic behaviors, the result may be a stable evolution or, reversely a chaotic behavior may be obtained by switching the parameter within a set of values corresponding to stable evolutions. This apparently surprising phenomenon is, in fact, a generalization of the known P...

1781608756

Upwelling in the Taiwan Strait during the summer monsoon detected by satellite and shipboard measurements

Remote Sensing of Environment, 2002

The Taiwan Strait is located at the confluence of the East China Sea and the South China Sea in the west Pacific Ocean. Several upwelling zones in the Taiwan Strait are noted for their high fisheries production; these upwelling zones have been studied in the past decade, but we have no overall picture on the size and temporal changes of these upwelling zones due to only limited in situ observation over short periods of time. The present paper investigates upwelling in the Taiwan Strait with satellite remote sensing data of NOAA-derived Sea Surface Temperature (SST) and SeaWiFS-derived Chlorophyll-a (Chl-a) and shipboard measurements during summer 1998. Results reveal five upwelling zones: (1) coastal upwelling near Pingtan Island (PTU), (2) coastal upwelling...

1781608756

The effect of microstructure on Rayleigh-Taylor instability growth in solids

J. Phys.: Conf. Ser., 2014

The effect that grain size and material processing have on high-strain rate deformation of copper has been assessed through measurements of unstable Rayleigh-Taylor (RT) perturbation growth. The dynamic loading conditions and initial sinusoidal perturbations imposed on the samples are kept constant while the microstructure of the sample material is varied. Different polycrystalline grain-sizes, single-crystal orientations, and strain-hardened samples have all been dynamically tested. The RT perturbation growth is measured by acquiring a time-sequence of radiographs using the Los Alamos National Laboratory Proton Radiography (pRad) Facility. Single-crystal orientation and stain hardening due to material processing are both observed to affect the perturbation ...

1781608756

Fluidizable Ni/La2O3-γAl2O3 catalyst for steam gasification of a cellulosic biomass surrogate

Applied Catalysis B: Environmental, 2014

This study reports a new fluidizable Ni catalyst supported on La2O3 modified γ-Al2O3. The 20% Ni/5% La2O3-γAl2O3 catalyst is prepared using a specially designed multistep incipient wetness technique and direct reduction of metal nitrate precursors. Steam gasification of glucose (a biomass surrogate), is developed in a CREC Riser Simulator using the new fluidizable catalyst. Experiments are performed at different steam/biomass ratios, temperatures and reaction times. Catalytic gasification runs confirm the high performance of the Ni/La2O3-γAl2O3 in terms of reforming activity, and reduced coke formation. Furthermore, observed gasification products (H2, CO, CO2, and CH4) are in agreement with thermodynamics, with product yields approaching chemical equilibr...

1781608756

CHD2-Related CNS Pathologies

IJMS, 2021

Epileptic encephalopathies (EE) are severe epilepsy syndromes characterized by multiple seizure types, developmental delay and even regression. This class of disorders are increasingly being identified as resulting from de novo genetic mutations including many identified mutations in the family of chromodomain helicase DNA binding (CHD) proteins. In particular, several de novo pathogenic mutations have been identified in the gene encoding chromodomain helicase DNA binding protein 2 (CHD2), a member of the sucrose nonfermenting (SNF-2) protein family of epigenetic regulators. These mutations in the CHD2 gene are causative of early onset epileptic encephalopathy, abnormal brain function, and intellectual disability. Our understanding of the mechanisms by which...

1781608756

Microdeletion syndrome 16p11.2‐p12.2: Clinical and molecular characterization

American J of Med Genetics Pt A, 2009

The pericentromeric region on 16p appears to be susceptible to chromosomal rearrangements and several patients with rearrangements in this region have been described. We report on a further patient with a microdeletion 16p11.2-p12.2 in the context of described patients with a deletion in the pericentromeric region of 16p. Minor facial anomalies, feeding difficulties, significant delay in speech development, and recurrent ear infections are common symptoms of the microdeletion syndrome 16p11.2-p12.2. All reported patients so far share a common distal breakpoint at 16p12.2 but vary in the proximal breakpoint at 16p11.2. The microdeletion 16p11.2-p12.2 should be distinguished from the approximately 500 kb microdeletion in 16p11.2 which seems to be associated wi...

1781608756

Small-scale experimental and theoretical analysis on maximum temperature beneath ceiling in tunnel fire with vertical shafts

Applied Thermal Engineering, 2017

By replacing jet fans with vertical shafts to facilitate ventilations, the installation and operating costs of a tunnel reduced drastically. However, compared to jet fans in tunnel ventilation which have been systematically studied, the ventilation efficiency of vertical shafts is much more complicated to be analyzed and theoretically proved as it is affected not only by the quantity of shafts, but also by the arrangements and the dimension of them. In order to provide theoretical support, small-scale experiments and theoretical analysis are carried out in this paper to predict the maximum temperature beneath ceiling when there is a fire in tunnel with vertical shafts. Firstly, a theoretical prediction model is deduced to calculate them under different shaft...

1781608756

Aberrant Muscle Antigen Exposure in Mice Is Sufficient to Cause Myositis in a Treg Cell–Deficient Milieu

Arthritis & Rheumatism, 2013

Myositis is associated with muscle-targeted inflammation and is observed in some Treg cell-deficient mouse models. Because an autoimmune pathogenesis has been strongly implicated, the aim of this study was to investigate the hypothesis that abnormal exposure to muscle antigens, as observed in muscle injury, can induce autoimmune-mediated myositis in susceptible hosts.FoxP3 mutant (scurfy) mice were mated to synaptotagmin VII (Syt VII) mutant mice, which resulted in a new mouse strain that combines impaired membrane resealing with Treg cell deficiency. Lymphocyte preparations from double-mutant mice were adoptively transferred intraperitoneally, with or without purified Treg cells, into recombination-activating gene 1 (RAG-1)-null recipients. Lymph node cells...

1781608756

Chemistry of thermal springs in the Larderello-Travale geothermal region, southern Tuscany, Italy

Applied Geochemistry, 1986

Thirty-two thermal spring, eleven cold spring and six steam condensates in the Larderello-Travale geothermal region have been studied from a geochemical point of view. The aim of this work was to delineate the relation between the chemical composition of the natural thermal manifestations and the thermal anomaly, which is among the best known in the world. The Larderello spring, both hot and cold, are characterized by low salinity (total dissolved solids generally lower than 1000 mg/kg), and alkaline-earth bicarbonate composition. In contrast, an alkaline-earth sulfate composition characterizes the thermal springs of the Travale area. This difference is due to the fact that the underground pathways of the Larderello hot springs are only in shallow flyschoid ...

1781608756

Color-based clustering algorithm as a novel image analytical method for characterizing maltose crystallinity in amorphous food models

Food Research International, 2021

Maltose crystallization affects the processibility and stability of sugar-rich foods. This study introduced a color-based clustering algorithm (CCA) to analyze crystallinity from the images of amorphous maltose/protein models. The XRD and DSC were also implemented in maltose crystallization characterization and validated the CCA analysis. The results indicated that CCA could effectively recognize maltose crystals (R = 0.9942), and amorphous maltose mainly crystallized to anhydrate α-maltose and β-maltose monohydrate according to its morphological aspects measured by CCA, XRD, and DSC. However, protein could change the mechanism of maltose crystal formation by disturbing the mutarotation and recrystallization processes of unstable β-maltose. Besides, malto...

1781608756

Effect of Welding Parameters on the Tensile Strength of the Weld-Deposition Layer

KEM, 2020

In general, tensile strength is an important factors when evaluating the quality of a product. In this study, samples are created using Wire Arc Additive Manufacturing (WAAM) technology. WAAM technology is a combination of Metal Active Gas welding technology and Computer numerical control technology, and is used to create products with a near net shape. Experimental process parameters, such as welding speed and welding current, are implemented and a deposition layer test is performed, where samples are deposited, layer-upon-layer, and then face milled to ensure the correct dimensions are achieved before subsequent deposition. Using specialized testing equipment, specific data is obtained in order to determine the tensile strength of the sample. Statistical m...

1781608756

On the physiologic role of beta-2 adrenoceptors in the human heart: In vitro and in vivo studies

American Heart Journal, 1990

To study the physiologic role of human myocardial beta-2 adrenoceptors, the beta adrenoceptor subtype(s) involved in the effects of catecholamines in vitro on the force of contraction and in vivo on heart rate were characterized. In vitro on both isolated electrically driven right and left atrial and left papillary muscle preparations, isoprenaline and adrenaline caused positive inotropic effects via beta-1 and beta-2 adrenoceptor stimulation. In the atria both beta-1 and beta-2 adrenoceptor stimulation increased contractile force to a maximum; in left papillary muscle, however, only beta-1 adrenoceptor stimulation maximally increased contractile force, whereas beta-2 adrenoceptor stimulation caused only submaximal increases. Noradrenaline, on the other hand...

1781608756

Intermittency transition to generalized synchronization in coupled time-delay systems

Phys. Rev. E, 2007

We report the nature of the transition to generalized synchronization (GS) in a system of two coupled scalar piecewise linear time-delay systems using the auxiliary system approach. We demonstrate that the transition to GS occurs via an on-off intermittency route and that it also exhibits characteristically distinct behaviors for different coupling configurations. In particular, the intermittency transition occurs in a rather broad range of coupling strength for the error feedback coupling configuration and in a narrow range of coupling strength for the direct feedback coupling configuration. It is also shown that the intermittent dynamics displays periodic bursts of periods equal to the delay time of the response system in the former case, while they occur ...

1781608756

Study on wetting deformation characteristics of coarse granular materials and its simulation in core‐wall rockfill dams

Num Anal Meth Geomechanics, 2020

Summary The wetting deformation of coarse granular materials is often considered to be an important cause of the core wall rockfill dam cracks during impounding. By analyzing existing research results, this paper proposes a hyperbolic relationship between the wetting axial strain and wetting stress level and puts forwards a warped surface relationship among spherical stress, shear stress, and the ratio of wetting volumetric strain to wetting axial strain. To illustrate its practicability, the wetting strain model's parameter determination process is introduced and the rockfill materials wetting parameters are determined using the triaxial wetting test data. Moreover, the collapse settlement of Guanyinyan rockfill dam during first impounding is numerically si...

1781608756

P3–207: Association of the –491 but not –219 APOE promoter polymorphism with Aβ₄₀ load as CAA in AD

Alzheimer's & Dementia, 2006

It is unknown whether either of the –491 and –219 polymorphisms of apolipoprotein E (APOE) promoter carries with it any increased risk for development of cerebral amyloid angiopathy (CAA) as result of amyloid beta (Aβ) deposition in AD. The purpose of this study was to investigate a potential association of APOE promoter polymorphisms with the extent of deposition of Aβ in CAA or senile plaques (SP), and the severity of arteriosclerosis (ART) and myelin loss (ML). Pathological measures of total Aβ, Aβ40 and Aβ42 loads as CAA or SP were taken from the immunostained sections. Severity of ART or ML was taken from the Haematoxylin and Eosin (HE) or Luxol fast blue (LFB) stained sections. APOE and coding and promoter polymorphisms genotyping had been per...

1781608756

A review of lane detection methods based on deep learning

Pattern Recognition, 2021

Lane detection is an application of environmental perception, which aims to detect lane areas or lane lines by camera or lidar. In recent years, gratifying progress has been made in detection accuracy. To the best of our knowledge, this paper is the first attempt to make a comprehensive review of vision-based lane detection methods. First, we introduce the background of lane detection, including traditional lane detection methods and related deep learning methods. Second, we group the existing lane detection methods into two categories: two-step and one-step methods. Around the above summary, we introduce lane detection methods from the following two perspectives: (1) network architectures, including classification and object detection-based methods, end-to-...

1781608756

Pricing and green level decisions of a green supply chain with governmental interventions under fuzzy uncertainties

Journal of Cleaner Production, 2017

Environmental issues make green manufacturing become inevitable and fuzzy uncertainty prevails in supply chain management. In order to further promote the development of green supply chain, according to channel leadership scenario, we develop three game models of a green supply chain with governmental interventions under fuzzy uncertainties of both manufacturing cost and consumer demand. We study how prices, green levels and expected profits are influenced by channel leadership and governmental interventions. Green level sensitivity and fuzzy degree of parameters are considered. Analytical results indicate that manufacturer Stackelberg scenario is the inferior structure than other scenarios and retailer Stackelberg scenario is superior to other scenarios for...

1781608756

Ropivacaine and bupivacaine for long-term epidural infusion in a small child

British Journal of Anaesthesia, 1999

Ropivacaine is assumed to be less toxic than bupivacaine but there are no reports concerning its long-term use in paediatric anaesthesia. We report the use of ropivacaine for long-term epidural anaesthesia in a 21-month-old girl. In two consecutive periods of 3 days each, 0.5% bupivacaine and 0.5% or 0.75% ropivacaine were administered to facilitate painful vaginal brachytherapy. The mean dose of bupivacaine increased from 1.05 to 1.32 mg kg-1 h-1 and that of ropivacaine increased from 1.40 to 3.86 mg kg-1 h-1. No toxic side effects were observed. We conclude that both epidural ropivacaine and bupivacaine were effective and safe during long-term epidural anaesthesia in this particular case. However, the doses were potentially toxic and should therefore be us...

1781608756

A newly recognized syndrome of severe growth deficiency, microcephaly, intellectual disability, and characteristic facial features

European Journal of Medical Genetics, 2014

Genetic syndromes with proportionate severe short stature are rare. We describe two sisters born to nonconsanguineous parents with severe linear growth retardation, poor weight gain, microcephaly, characteristic facial features, cutaneous syndactyly of the toes, high myopia, and severe intellectual disability. During infancy and early childhood, the girls had transient hepatosplenomegaly and low blood cholesterol levels that normalized later. A thorough evaluation including metabolic studies, radiological, and genetic investigations were all normal. Cholesterol metabolism and transport were studied and no definitive abnormality was found. No clinical deterioration was observed and no metabolic crises were reported. After due consideration of other known here...

1781608756

A unified micromechanics-based damage model for instantaneous and time-dependent behaviors of brittle rocks

International Journal of Rock Mechanics and Mining Sciences, 2016

This paper presents a unified micromechanics-based damage model for instantaneous and time-dependent inelastic behaviors of brittle rocks subjected to compressive stresses. The constitutive model is formulated in a combined homogenization/thermodynamics framework. The inelastic deformation is induced by frictional sliding along closed cracks, and strongly coupled with damage evolution by crack growth. Material degradation is described by a scalar-valued internal damage variable that is decomposed into two parts: an instantaneous part induced by applied stresses and a time-dependent part by subcritical cracking due to stress corrosion. Based on the system free energy determined with the Mori–Tanaka homogenization scheme, we propose a Coulomb-type friction c...

1781608756

Study of pharmacokinetics of an in situ forming gel system for controlled delivery of florfenicol in pigs

Vet Pharm & Therapeutics, 2015

To reduce florfenicol (FFC) administration frequency in veterinary use, the drug was currently developed into in situ forming gel. Twelve pigs were randomly divided into two groups (six pigs per group). A single i.m. dose of 40 mg/kg body weight (b.w.) was given to pigs, group one was given FFC in situ forming gel, and group two was given FFC conventional injection. High-performance liquid chromatography (HPLC) was used to determine FFC plasma concentrations. There were significant differences (P < 0.01) between FFC in situ forming gel and conventional injection, in pharmacokinetic parameters MRT (mean retention time) (57.79 ± 2.88) h versus (15.94 ± 1.29) h, AUC (area under the concentration-time curve) (421.54 ± 8.97) μg·h/mL versus (168.16 ± 4.59) �...

1781608756

Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains

PLoS ONE, 2009

We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in response to chronic administration of a single dose of the beta-adrenergic receptor blocker atenolol or under a low and a high dose of the beta-agonist isoproterenol and compared to baseline condition. The robustness of our data is supported by high trait heritabilities (typically H(2)>0.7) and significant correlations of trait values measured in baseline condition with independent multistrain datasets of the Mouse Phenome Database. We then focused on the drug-, dose-, and strain-specific responses to beta-stimulation and beta-blockade of a selection of traits including heart rate, systolic blood pressure, cardiac weight indices, ECG ...

1781608755

EMI from cavity modes of shielding enclosures-FDTD modeling and measurements

IEEE Trans. Electromagn. Compat., 2000

Electromagnetic interference (EMI) from slots and apertures resulting from coupling of interior sources through enclosure cavity modes in a rectangular test enclosure is reported. EMI from a specially designed test enclosure with slots or apertures excited by interior sources was studied experimentally and with finite-difference time-domain (FDTD) modeling. The measurements and FDTD modeling agree well. The results indicate that radiation at cavity mode resonances through slots and apertures of nonresonant dimensions can be as significant as the radiation at aperture or slot resonances. The agreement between the FDTD modeling and measurements demonstrates the usefulness of FDTD for investigating aspects of shielding enclosure design such as coupling to slots...

1781608755

Ceramic foams and micro-beads from emulsions of a preceramic polymer

Journal of the European Ceramic Society, 2011

A commercially available solid silicone resin was dissolved in a solvent and emulsified via stirring in the presence of water and surfactant to form three different types of emulsions, namely water-in-oil (w/o), water-in-oil-in-water (w/o/w) and oil-in-water (o/w), by following different preparation procedures. After curing, thermosets possessing different morphologies, ranging from highly porous (monolithic) foams to porous micro-beads and solid micro-beads, formed. The samples kept their shape upon pyrolysis, and resulted in ceramic foams (via w/o) and porous micron sized (∼200 μm) spherical particles (via w/o/w) having more than 80 vol% of total porosity, while with o/w emulsification solid SiOC ceramic particles with an average diameter of ∼100 μm ...

1781608755

809-4 Effect of Beta Adrenergic Stimulation on Regional Norepinephrine Spillover in Human Congestive Heart Failure

Journal of the American College of Cardiology, 1995

Beta blockers may be effective therapy in congestive heart failure; the reasons are not fully clear norepinephrine (NE) rel. Presynaptic beta-1 receptors are known to facilitateease. If this effect occurs in congestive heart failure (CHF) an important positive feedback loop might exist contributing to chronic sympathetic activation; conversely, interference with such an interaction could contribute to beneficial effects of beta adrenergic blockade. To test the hypothesis that beta simulation would lead to increased local sympathetic activity we measured regional forearm NE kinetics (clearance method of Esler with 3HNE) during intraarterial infusion of subsystemic doses of isoproterenol (ISU) in 6 patients with chronic stable, moderate CHF. As a control for f...

1781608755

A distribution-free method using maximum entropy and moments for estimating probability curves of rock variables

International Journal of Rock Mechanics and Mining Sciences, 2004

Reservoir sandstone contains pre-existing weaknesses, and its fluid flow properties may be altered when subjected to mechanical loading. Simulation of the complete deformation process of reservoir sandstone and its fluid transportation is important in the fields of rock mechanics and gas production. Based on the statistical damage theory with consideration of void volume changes and fluid pressure, a new constitutive model was developed to describe the mechanical characteristics of saturated porous media in geo-materials. On the basis of the Weibull distribution for rock micro-strength, the damage variable was defined and a semi-analytical permeability variation model was established. Experimental results demonstrated that the theoretical model was in good a...

1781608755

Prognostic value of pulmonary congestion assessed by lung ultrasound to predict decompensation in heart failure patients

Archives of Cardiovascular Diseases Supplements, 2020

Lung ultrasound (LUS) evaluation of B lines has been demonstrated to be a valid tool for the assessment and monitoring of pulmonary congestion in heart failure (HF) patients. Data on the long-term outcome of patients presenting with B lines is lacking. The aim of this study was to evaluate their long-term prognosis, with a primary endpoint of rehospitalization for heart failure and/or death. Ninety-one patients presenting with significant dyspnea (NYHA ≥ 2) underwent an initial analysis of LUS for B-lines, complete TTE and left heart catheterization to evaluate left ventricular end diastolic pressure (LVEDP). They were prospectively followed up for an average duration of 803 days ± 113 days. 13 patients presented with heart failure, and 13 patients died. ...

1781608755

The Effect of Speaking Rate on the Role of the Uniqueness Point in Spoken Word Recognition

Journal of Memory and Language, 2000

Using gender decision and shadowing tasks, we compared recognition of French nouns with early or late uniqueness points (UP) that were articulated at three different rates. With gender decision, the medium rate (3.6 syllables (syll)/s), which is close to that used by Radeau, Mousty, and Bertelson (1989), gave rise to a comparable UP location effect. The effect increased at the slower rate (2.2 syll/s), but disappeared at the faster rate (5.6 syll/s). With shadowing, only the slow rate gave rise to a UP effect. A similar pattern of results was found using speech that was linearly compressed or expanded. Because the fast rate is close to that typical of conversational speech, the present results cast doubt on the relevance of the UP in the processing of fluent...

1781608755

Chinese rural reform in 30 years: An analysis in terms of institutional economics

Front. Econ. China, 2010

Both from history and logic, the rural reform is the starting point for China’s overall economic reform. The gradualism, inherent logical evolution and interest conflict of reform in China all have their origins in rural reform. The thirty-year’s rural reform can be viewed as the adjustment of urban-rural relations by different period. This study adopts the analytical framework of institutional economics to clearly demonstrate the whole logic process of institutional transition, then from the international comparative perspective, generalizes some basic experiences in China’s rural reform and the lessons for developing and transitional countries. On the basis of judging different stages of economic development, this paper also sums up the new challenge...

1781608755

Bidding Wars Over R&D-Intensive Firms: Knowledge, Opportunism, and the Market for Corporate Control

Academy of Management Journal, 2003

There are number of competing (and complementary) theories of the firm seeking to explain the scope and boundaries of organizations. Two prominent competitors are the knowledge-based theory of the firm (KBTF) and transaction cost economics (TCE). These differ in that the KBTF seeks to explain the scope and existence of firms independent of opportunism, the driving force behind transaction cost economics (TCE). The KBTF implies that, as knowledge intensity increases, organizational boundary decisions are increasingly driven by knowledge management concerns, rather than by opportunism. For example, there may be a need to co-locate functions to facilitate knowledge transfer or communication. If this is true, then as R&D-intensity increases, the KBTF should gain...

1781608755

Differentiation of beta 1- and beta 2-adrenoceptor-mediated effects in humans

American Journal of Physiology-Heart and Circulatory Physiology, 1988

To differentiate beta 1- and beta 2-adrenoceptor-mediated effects in humans, we studied the effects of a 2-wk treatment of 12 male volunteers with the selective beta 1-adrenoceptor antagonist bisoprolol (1 x 10 mg/day) and the beta 2-selective antagonist ICI 118,551 (3 x 25 mg/day) on lymphocyte beta 2-adrenoceptor density and responsiveness [10 microM l-isoproterenol (IPN) evoked adenosine 3',5'-cyclic monophosphate (cAMP) increase] as well as on exercise- and IPN-induced changes in lymphocyte beta 2-adrenoceptor density, blood pressure, heart rate, and plasma norepinephrine levels. ICI 118,551 administration increased lymphocyte beta 2-adrenoceptor density and responsiveness by approximately 50%, whereas bisoprolol had no effect. Dynamic exercise on a bicy...

1781608755

A Comparison of Ethanol Partitioning in Biological and Model Membranes: Nonideal Partitioning is Enhanced in Synaptosomal Membranes

Alcoholism Clin & Exp Res, 1989

The partitioning of ethanol into mouse brain synaptosomes at 37 degrees C was characterized as a function of ethanol concentration. In addition, the partitioning of ethanol into multilamellar dipalmitoylphosphatidylcholine (DPPC) vesicles was characterized as a function of ethanol concentration and temperature. DPPC liposomes provided a model for ethanol partitioning into a phospholipid bilayer of defined composition allowing comparison to the more complex synaptosomal membrane. The values of the partition coefficients for ethanol depend on the convention used to express concentration in the partition coefficient ratio. We express these concentrations as mole fractions as ethanol in the membrane and aqueous phases. Ethanol partitioning is nonideal (ethanol m...

1781608755

Segmentation of gray matter, white matter, and CSF with fluid and white matter suppression using MP2RAGE

Magnetic Resonance Imaging, 2018

Background MP2RAGE can generate uniform T1-weighted images, which have been used for brain segmentation. However, there remain concerns about carrying out fast brain segmentation. Purpose To propose an acquisition-based method for fast segmentation of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) of healthy human brains with fluid and white matter suppression (FLAWS) using MP2RAGE. Study Type Prospective. Subjects 12 volunteers (23–28 years, seven subjects; 51–62 years, five subjects). Field Strength/Sequences 3T/3D MPRAGE and FLAWS. Assessment The proposed method was evaluated by calculating tissue volumes and the spatial overlap with the segmentation results from FSL and SPM12. The processing time was recorded. Statistical Tests A ...

1781608755

Transient displacement of a viscoplastic material by air in straight and suddenly constricted tubes

Journal of Non-Newtonian Fluid Mechanics, 2003

We examine the transient displacement of a viscoplastic material from straight or suddenly constricted cylindrical tubes of finite length. Our general goal is to develop accurate and efficient numerical methods for the fundamental study of processes in which a gas is displacing a liquid from prototype geometries under various operating conditions. Such processes can be part of the Gas Assisted Injection Molding (GAIM) or enhanced oil recovery. To this end, we use the mixed finite element method coupled with a quasi-elliptic mesh generation scheme in order to follow the very large deformations of the fluid volume. The displacing fluid is gas at high pressure, which forms a bubble of increasing length and a shape that depends on the fluid properties, the flow ...

1781608755

L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance

Sci Rep, 2019

Abstract Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD 2 in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 ( fabp4 , aP2 ) -Cre/L-PGDS flox/flox and adiponectin ( AdipoQ ) -Cre/L-PGDS flox/flox mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. The L-PGDS expression and PGD 2 production levels decreased in white adipose tissue (WAT) under HFD conditions only in the aP2-Cre/L-PGDS flox/flox mice, but were uncha...

1781608755

A novel peptide suppresses adipogenic differentiation through activation of the AMPK pathway

Biochemical and Biophysical Research Communications, 2019

Obesity rates have risen rapidly over the past several decades and obesity is now a global public health challenge. The reduction of excessive adipogenesis is thought to be an effective intervention for obesity and obesity-related metabolic diseases such as type 2 diabetes. In this study, a novel peptide PDBSN was identified that functions to suppress adipogenesis. In both human preadipocytes and mouse adipose-derived stem cells (ADSCs), PDBSN exhibited a suppressive effect on the accumulation of lipids and the expression of genes as well as their corresponding proteins (CCAAT/enhancer binding protein (C/EBP)β, C/EBPα and nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ)) relevant to adipogenic cell differentiation. Although adipogene...

1781608755

Ab initio calculation of the thermochemical properties of polysulphanes (H2S )

Chemical Physics Letters, 1998

Thermochemical properties of gaseous polysulphanes (H 2 S n ) were calculated using the G2 and CBS-Q ab initio theoretical methods. The temperature dependence of the heat capacities and entropies for the polysulphanes are computed between 300 and 1000 K. The difference between the available experimental heat capacity of disulphane (298 K) and the calculated one is found to be quite small (0.7 cal/mol K). The latter is indicative of hindered internal rotation in polysulphanes. Ab initio calculations of rotational barriers in polysulphanes show that the relatively high barriers of internal rotations can be due to the interplay of attractive stabilization, π-character of the S–S bonds (due to hyperconjugation effects) and the participation of the sulphur 3d ...

1781608755

Elution characteristics of 99 Tcm-labelled erythrocytes in relation to scintigraphic detection of gastrointestinal bleeding

Nuclear Medicine Communications, 1991

Radionuclide imaging for the detection and localization of gastrointestinal bleeding is a highly sensitive and well-established clinical tool. 99Tcm-labelled erythrocytes have permitted the recognition of intermittent bleeding up to 24 h following injection. However, free pertechnetate is actively secreted by gastric mucosa and can result in confounding gut activity. The possibility that pertechnetate may elute from the radiolabelled erythrocytes was investigated in an in vitro model. Blood samples from five subjects undergoing gated cardiac studies were labelled by modified in vivo, modified in vitro and pure in vitro methods and then incubated in serum for 24 h. Automated cell counts and instant thin layer chromatography were used to measure the physical a...

1781608755

Multi-Axis EDM CNC System Based on RT-Linux

KEM, 2009

In order to manufacture geometrically complex or hard material parts, a new kind of multi-axis electro-discharge machining (EDM) computer numerical control (CNC) system, which is based on RT-Linux platform, was presented. Dual-kernel structure of System is adopted: Linux and RT-Linux are used to realize Time-sharing tasks and Real-time tasks separately. The system is divided macroscopically into two parts: Real-time part and Time-sharing part, microcosmically into three modules: Real-time Control Module, Drive Module and CNC User Module. Through the communications among them, three modules construct the whole system. Rimed Turbine Blisk was experimentalized to validate the performance of the system. The process and the results implied that the system is Real...

1781608755

ON BEING MOTHER AND PATIENT: DIALECTICAL STRUGGLES DURING MEDICALLY HIGH‐RISK PREGNANCY

Infant Mental Health Journal, 2018

Medically high-risk pregnancy (MHRP) affects 3 to 10% (diagnosis-dependent) of pregnant women in the United States (National Institute of Child Health Development, 2015), threatening maternal and fetal well-being. Although mothers' prenatal distress and mother-infant attachment after birth have been quantitatively researched, little research has examined women's lived experiences of MHRP in the United States. We examined 16 women's experiences of MHRP during hospitalization at an urban, Northeastern U.S. hospital using an interpretive phenomenological approach. Our qualitative findings provide new understanding of how women expend tremendous energy simultaneously navigating new roles of mother and patient. While negotiating these roles, they experienced dial...

1781608755

Assessing the effects of service quality on customer satisfaction

10.5267/j.msl, 2019

A constant concern of academic institutions has been to improve the customer satisfaction in university libraries.The service quality within academic library context is pivotal for satisfying customers by meeting the customers' needs to create loyalty amongst customers.This research uses LibQual to analyze the gap between customer's perception and expectation, concerned with the services at the University Sultan Zainal Abidin (UniSZA) Library.There are six dimensions in service quality; namely general services, search for materials, library collection, staff, environment and environment, considered for this empirical research.The purpose of this paper is to 1) know service quality dimensions that satisfy the customers and 2) to observe the impact of service ...

1781608755

Microarray evaluation of EP4 receptor-mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation

Biochemical and Biophysical Research Communications, 2004

Prostaglandin E2 (PGE2) has been shown to negatively regulate adipogenesis. To explore to what extent PGE2 inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells exposed to a differentiation cocktail supplemented with PGE2, AE1-329 (an EP4 agonist), or vehicle. The differentiation-associated responses in genes such as adipocytokines and enzymes related to lipid metabolism were largely weakened upon PGE2 treatment. In particular, the expression of peroxisome proliferator activated receptor-γ and CCAAT/enhancer binding protein-α, genes playing a central role in adipogenesis, was greatly suppressed. PGE2 appears to...

1781608755

Improving the Efficiency of Hematite Nanorods for Photoelectrochemical Water Splitting by Doping with Manganese

ACS Appl. Mater. Interfaces, 2014

Here, we report a significant improvement of the photoelectrochemical (PEC) properties of hematite (α-Fe2O3) to oxidize water by doping with manganese. Hematite nanorods were grown on a fluorine-treated tin oxide (FTO) substrate by a hydrothermal method in the presence on Mn. Systematic physical analyses were performed to investigate the presence of Mn in the samples. Fe2O3 nanorods with 5 mol % Mn treatment showed a photocurrent density of 1.6 mA cm–2 (75% higher than that of pristine Fe2O3) at 1.23 V versus RHE and a plateau photocurrent density of 3.2 mA cm–2 at 1.8 V versus RHE in a 1 M NaOH electrolyte solution (pH 13.6). We attribute the increase in the photocurrent density, and thus in the oxygen evolving capacity, to the increased donor density ...

1781608755

Choice of material in the design of permanent magnet flux sources

IEEE Trans. Magn., 1993

To determine the temperature dependence of the magnetization of three commercial high energy product permanent magnet materials under conditions approximating those in a permanent magnet circuit, a method is devised whereby measurements are made at values of mu /sub L/=B/ mu /sub 0/H that remain constant as the temperature is varied. All the values of mu /sub L/ used are on the same spherical sample for any given material. The values of mu /sub L/ range from zero to ten thousand to mimic almost any circumstance likely to be encountered in most real permanent magnet circuits. The method of measurement is described, and an example of the material selection procedure for an actual magnetic circuit is given.<

1781608754

Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase

Protein Expression and Purification, 2007

FAD synthetase (FADS) (EC 2.7.7.2) is a key enzyme in the metabolic pathway that converts riboflavin into the redox cofactor FAD. The human isoform 2 of FADS (hFADS2), which is the product of FLAD1 gene, was over-expressed in Escherichia coli as a T7-tagged protein and identified by MALDI-TOF MS analysis. Its molecular mass, calculated by SDS–PAGE, was approx. 55 kDa. The expressed protein accounted for more than 40% of the total protein extracted from the cell culture; 10% of it was recovered in a soluble and nearly pure form by Triton X-100 treatment of the insoluble cell fraction. hFADS2 possesses FADS activity and has a strict requirement for MgCl2, as demonstrated in a spectrophotometric assay. The purified recombinant isoform 2 showed a kcat of 3.6 �...

1781608754

Inotropic and Sympathetic Responses to the Intracoronary Infusion of a β₂-Receptor Agonist

Circulation, 1999

Background —On the basis of the presence of β 2 -receptors within the sympathetic nervous system, β 2 -stimulation may increase cardiac sympathetic outflow. We addressed the hypothesis that sympathoexcitatory β 2 -receptors are present in the human left ventricle. Methods and Results —The β 2 -agonist salbutamol was infused into the left coronary artery in 3 groups of patients: group 1 (n=9, no β-blocker therapy), group 2 (n=7, β 1 -selective blockade with atenolol), and group 3 (n=6, nonselective β-blockade with nadolol). Left ventricular +dP/dt in response to increasing concentrations of salbutamol was measured in all groups, and cardiac norepinephrine spillover was measured in group 1. There were no systemic hemodynamic changes in any group. Sa...

1781608754

Effect of surface nano-modification on the antioxidation properties of Si3N4 ceramics

Journal of Alloys and Compounds, 2018

The application of Si3N4 ceramics is effectively limited due to the catastrophic failure which is caused by the oxidation weight gain. Nano-modification on the surface of Si3N4 micropowders is prepared to reduce the oxidation weight gain of Si3N4 ceramics. After modification, the Si3N4 particles are encapsulated completely by spherical nano-SiO2, which can obviously reduce the oxidation weight gain of the Si3N4 ceramics for the good sealing effect of dense SiO2 coatings. The finally oxidation weight gain rate of the Si3N4 ceramics reduces about 54.3% at 1580 °C. The nano-SiO2 coatings can also increase the surface area of Si3N4 particles, which can improve the sintering extent of the Si3N4 ceramics through accelerating the gradual strengthening of bonding n...

1781608754

Physiological role of β2-adrenoceptors in the atrioventricular nodal conduction in the dog

European Journal of Pharmacology, 1990

We investigated blocking effects of the selective β1-adrenoceptor blocker atenolol (0.1–100 μg/kg, i.v.), the selective β2-adrenoceptor blocker ICI 118,551 (1–1000 μg/kg, i.v.) and the combination of the two drugs on positive chronotropic and dromotropic responses to norepinephrine (NE) released by stimulation of the sympathetic nerves in anesthetized, neurally decentralized, open-chest dogs after atropine was given. Stimulation of the intracardiac sympathetic nerves to the SA nodal region or to the AV nodal region selectively increased heart rate or decreased AV conduction time, respectively. ICI 118,551 inhibited the chronotropic or dromotropic response to each stimulation in a dose-dependent manner, but its inhibition of the dromotropic response w...

1781608754

The influence of Si/Al ratio on the catalytic property and hydrothermal stability of Cu-SSZ-13 catalysts for NH3-SCR

Applied Catalysis A: General, 2018

Abstract Cu-SSZ-13 catalysts with three Si/Al ratios of 6, 15 and 30 were synthesized by a one-pot method. The catalytic property and hydrothermal stability of as-prepared catalysts were studied to understand the influence of Si/Al ratio on the NH3-SCR performance over Cu-SSZ-13 catalysts. Although the three catalysts contain equivalent Cu loading, they perform different catalytic activities for NO reduction. The EPR and H2-TPR results clearly show that the Si/Al ratio not only has influence on the nature of Cu species but also on the Cu species distribution. With increasing the Si/Al ratio, the amount of CuO increases while the number of highly stable Cu+ ions decreases. Such a phenomenon could be attributed to the less Al content in high-Si/Al-ratio cataly...

1781608754

A wavelet-based image denoising using least squares support vector machine

Engineering Applications of Artificial Intelligence, 2010

The least squares support vector machine (LS-SVM) is a modified version of SVM, which uses the equality constraints to replace the original convex quadratic programming problem. Consequently, the global minimizer is much easier to obtain in LS-SVM by solving the set of linear equation. LS-SVM has shown to exhibit excellent classification performance in many applications. In this paper, a wavelet-based image denoising using LS-SVM is proposed. Firstly, the noisy image is decomposed into different subbands of frequency and orientation responses using the wavelet transform. Secondly, the feature vector for a pixel in a noisy image is formed by the spatial regularity in wavelet domain, and the LS-SVM model is obtained by training. Then the wavelet coefficients a...

1781608754

Thermodynamic studies and parametric effects on exergetic performance of a steam power plant

International Journal of Ambient Energy, 2017

ABSTRACTA comprehensive thermodynamic analysis is conducted for an existing 82 MW steam power plant. A detailed assessment on energy loss and exergy destruction for individual components of plants (including boiler sub-parts) is reported. A code is built in EES to evaluate the energy loss, energy efficiency, physical and chemical exergies, exergy efficiency and exergy destruction for each part of plant by considering the real values’ range of operating parameters. Analysis pointed out that the main sources of exergy destruction are boilers followed by the turbines, deaerators and then condensers. In boiler, combustor contributes about 50% in total exergy destruction. The maximum energy loss is reported in boilers followed by condensers, in piping, due to...

1781608754

Heat transfer and thermal stress analysis in fluid-structure coupled field

Applied Thermal Engineering, 2015

In this work, three-dimensional simulation on conjugate heat transfer in a fluid-structure coupled field was carried out. The structure considered is from the dual-coolant lithium-lead (DCLL) blanket, which is the key technology of International Thermo-nuclear Experimental Reactor (ITER). The model was developed based on finite element-finite volume method and was employed to investigate mechanical behaviours of Flow Channel Insert (FCI) and heat transfer in the blanket under nuclear reaction. Temperature distribution, thermal deformation and thermal stresses were calculated in this work, and the effects of thermal conductivity, convection heat transfer coefficient and flow velocity were analyzed. Results show that temperature gradients and thermal stresses ...

1781608754

Effect of Low-Dose Endotoxin on Pulmonary Vascular Permeability Following Acute Hemorrhagic Shock

Respiration, 1995

The purpose of the current study was to determine the effect of low-dose Escherichia coli lipopolysaccharide (LPS) on pulmonary vascular permeability when administered after hemorrhagic shock (40% of baseline cardiac output) followed by resuscitation. Animals were monitored for 3-4 h after LPS infusion. Thirty minutes prior to termination of the experiment, 3 mCi of 125I-human serum albumin was injected intravenously to calculate a permeability index from the left lung lavage and plasma 125I ratios. The two control groups were (1) shock only (no LPS, n = 4), and (2) LPS only (no shock, n = 8). The permeability index for the shock-only group was 0.0015 +/- 0.0007 (mean +/- SE) and that for the LPS-only group was 0.0035 +/- 0.0014. The permeability index for t...

1781608754

Cardiac Resynchronization: Feasability of a Simplified Procedure

Europace, 2005

Multisite pacing procedures are X-ray andtime consuming and difficult. Our aim was to determine whether a simple procedure is effective, safe and faster. A coronary sinus (CS) angiography is performed prior to implantation. Even with thin or twisted target vein, we tried to catheterize directly CS and target vein using different stylets type and curves. The lead choice (OTW or standard) was discussed before each procedure. In case of failure, the standard procedure (sheath ± angioplasty guide wire) was tried. 27 pts were evaluated from 05-04 to 12-04. The target vein size was thin with 7 pts, medium with 11 pts and large with 9 pts. An OTW lead was chosen for 8 pts. 2 pts failed to be implanted with both techniques and 2 pts were implanted using the standar...

1781608754

Expanding the phenotypic and mutational spectrum in microcephalic osteodysplastic primordial dwarfism type I

American J of Med Genetics Pt A, 2012

Mutations in the RNU4ATAC gene cause microcephalic osteodysplastic primordial dwarfism type I. It encodes U4atac, a small nuclear RNA that is a component of the minor spliceosome. Six distinct mutations in 30 patients diagnosed as microcephalic osteodysplastic primordial dwarfism type I have been described. We report on three additional patients from two unrelated families presenting with a milder phenotype of microcephalic osteodysplastic primordial dwarfism type I and metopic synostosis. Patient 1 had two novel heterozygous mutations in the 3′ prime stem-loop, g.66G > C and g.124G > A while Patients 2 and 3 had a homozygous mutation g.55G > A in the 5′ prime stem-loop. Although they manifested the known spectrum of clinical features of microcephalic os...

1781608754

Emotion regulation difficulties interact with negative, not positive, emotional eating to strengthen relationships with disordered eating: An exploratory study

Appetite, 2021

Disordered eating includes core eating disorder symptoms present in diverse populations. The extant literature has focused on associations between negative emotional eating and disordered eating to the exclusion of positive emotional eating. Emotion regulation may help explain relationships between emotional eating and disordered eating. Emotion regulation difficulties was examined as a moderator of relationships between negative and positive emotional eating and disordered eating including dietary restraint, eating, weight, and shape concerns, and global scores of disordered eating, a general index of disordered eating. A cross-sectional study was employed using a university student population in the United States. Participants completed surveys assessing n...

1781608754

Depth-Related Effects on a Meiofaunal Community Dwelling in the Periphyton of a Mesotrophic Lake

PLoS ONE, 2015

Periphyton is a complex assemblage of micro- and meiofauna embedded in the organic matrix that coats most submerged substrate in the littoral of lakes. The aim of this study was to better understand the consequences of depth-level fluctuation on a periphytic community. The effects of light and wave disturbance on the development of littoral periphyton were evaluated in Lake Erken (Sweden) using an experimental design that combined in situ shading with periphyton depth transfers. Free-living nematodes were a major contributor to the meiofaunal community. Their species composition was therefore used as a proxy to distinguish the contributions of light- and wave-related effects. The periphyton layer was much thicker at a depth of 30 cm than at 200 cm, as indica...

1781608754

Comparison of immunological effects of Fullerene C60 and raw soot from Fullerene production on alveolar macrophages and macrophage like cells in vitro

Experimental and Toxicologic Pathology, 1996

Two carbon modifications, C60 and Raw Soot (RS) from fullerene production, were incubated with macrophages and macrophage-like cells. Their effects were compared both to DQ12 Quartz as a positive particle control known to damage BAM and HL60M, and LPS or zymosan as biological inducers of immunological reactions. C60 as well as RS are not cytotoxic as compared to DQ12. C60 seems to induce a lower chemotactic activity than RS and DQ12. Furthermore, C60 is of no or only very little influence on the formation of reactive oxygen species (ROS). RS itself is oxidatively active both with H2DFC-DA in in vitro cell culture and with KMB in a cell free incubation under the influence of light. It is not yet clear whether the in vitro effects of RS are caused by ROS forma...

1781608754

Reducing the Formation of Acrolein from Linolenate-Rich Oil by Blending with Extra Virgin Olive Oil during Repeated Frying of Food at High Temperatures

FSTR, 2018

Vegetable oils have long been used in cooking. However, repeated heating at a high temperature results in the gradual deterioration of the vegetable oils through oxidative degradation of fatty acids, leading to the formation of undesirable and irritating odors (e.g., acrolein). Linolenic acid is the main source of the acrolein formed during the heating of vegetable oils. The present study has developed a method to reduce the formation of acrolein during repeated frying with vegetable oils. Electronic nose analysis showed that the formation of acrolein from low-linolenic oil such as extra virgin olive oil (EVOO) was much lower than from a linolenic-rich oil, salad oil, when frying French fries. Blending EVOO with salad oil effectively reduced the amount of ac...

1781608754

Concept maps: a technique for assessing knowledge manager learning needs

Knowledge Management Research & Practice, 2009

This paper discusses an exploratory investigation of the role of concept mapping techniques for assessing knowledge manager learning needs and developing knowledge management (KM) training programs and courses. The research data were collected using seven concept map templates completed by 13 KM students during a 15-week higher education course. The study found that concept maps can provide a useful real-time feedback mechanism for knowledge managers undergoing structured learning, while enabling instructors to determine what KM practitioners require from their training and education. Additionally, the research showed that knowledge managers require a balance of foundational KM principles, concepts and methods coupled with examples of real-world implementati...

1781608754

Contrast-enhanced US for the Interventional Radiologist: Current and Emerging Applications

RadioGraphics, 2020

US is a powerful and nearly ubiquitous tool in the practice of interventional radiology. Use of contrast-enhanced US (CEUS) has gained traction in diagnostic imaging given the recent approval by the U.S. Food and Drug Administration (FDA) of microbubble contrast agents for use in the liver, such as sulfur hexafluoride lipid–type A microspheres. Adoption of CEUS by interventional radiologists can enhance not only procedure guidance but also preprocedure patient evaluation and assessment of treatment response across a wide spectrum of oncologic, vascular, and nonvascular procedures. In addition, the unique physical properties of microbubble contrast agents make them amenable as therapeutic vehicles in themselves, which can lay a foundation for future therape...

1781608754

Role of eicosanoids in hypoxic vasoconstriction in isolated lamb lungs

American Journal of Physiology-Heart and Circulatory Physiology, 1987

To determine the role of eicosanoids in hypoxic pulmonary vasoconstriction, we studied 42 isolated, blood-perfused lamb lungs during normoxia and hypoxia. We used the lung micropuncture technique to measure microvascular pressures in 20- to 80-micron diameter arterioles and venules and estimated segmental vascular resistance. In separate experiments, lungs were untreated or treated with either indomethacin (a cyclooxygenase inhibitor), Dazmegrel (a thromboxane synthetase inhibitor), SQ 29548 (a thromboxane receptor blocker), FPL 57231 (a leukotriene receptor blocker), or U 60257 (a 5'lipoxygenase inhibitor). In control untreated lungs both pulmonary arteries and veins constricted during hypoxia. Addition of indomethacin, Dazmegrel, or SQ 29548 to the perfusa...

1781608754

Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood

Reproductive Toxicology, 2007

Fetal exposure to phthalates may be associated with adverse reproductive effects, including cryptorchidism and decreased semen quality. Information about human placental transfer is needed to qualify the hypotheses. A dual recirculating placenta perfusion system to monitor concentrations of eight phthalate monoesters in fetal and maternal perfusates was established. In addition to perfusate background measures of phthalate monoesters, the concentrations in umbilical cord plasma and placenta tissue were measured. Monomethyl phthalate (mMP), monoethyl phthalate (mEP), monobutyl phthalate (mBP), and mono (2-ethyl-hexyl) phthalate (mEHP) were detected in both maternal and fetal perfusate, demonstrating a release of compounds from tissue or blood to perfusates. T...

1781608753

A comprehensive investigation of plowing and grain-workpiece micro interactions on 3D ground surface topography

International Journal of Mechanical Sciences, 2018

Abstract The accumulation of plowing effect in the grinding process which is ignored in previous researches has an essential influence on the surface topography of the workpiece. In this study, a new grinding surface topography modeling method considering the plowing effect is proposed. The modeling method of the grinding wheel based on the replicated method is given to obtain the real and accurate wheel surface topography. According to the cutting path of abrasive particles extracted from the wheel topography, the instantaneous undeformed chip thickness is calculated to determine the contact stages of rubbing, plowing and cutting. The influence of material accumulation caused by the plowing effect on the microstructure is discussed, and the mechanism of com...

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